ArticleG3 (Bethesda, Md.)2017
Open access · goldAbstract read
In one paragraph
Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.Nature genetics · 2022Pooled it
- From GWAS Signals to Molecular Mechanisms: Explainable AI for Causal Gene Prioritization and Biomolecular Target Interpretation.Biomolecules · 2026Review
- Genomic Structural Equation Modeling Provides an Initial View of the Genetic Architecture Related to Type 1 Gaucher Disease.Human mutation · 2026Article
- The breadth and impact of the Global Lipids Genetics Consortium.Current opinion in lipidology · 2025Review
- Association Between rs2278426 Polymorphism of theDiabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Strategies for the Genomic Analysis of Admixed Populations.Annual review of biomedical data science · 2023Review
- Energy Homeostasis Gene Nucleotide Variants and Survival of Hemodialysis Patients-A Genetic Cohort Study.Journal of clinical medicine · 2022Article
- Triangulating Molecular Evidence to Prioritize Candidate Causal Genes at Established Atopic Dermatitis Loci.The Journal of investigative dermatology · 2021Article
- Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci.PLoS genetics · 2021Article
- Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power.Nature genetics · 2021Article
- Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations.Circulation research · 2020Review
- Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits.G3 (Bethesda, Md.) · 2019Article
- Article
- Association between rs2278426 (C/T) and rs892066 (C/G) variants of ANGPTL8 (betatrophin) and susceptibility to type2 diabetes mellitus.Journal of clinical laboratory analysis · 2019Article
- The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity.Cardiovascular diabetology · 2018Article
- Deciphering the Emerging Complexities of Molecular Mechanisms at GWAS Loci.American journal of human genetics · 2018Review
- From genome-wide associations to candidate causal variants by statistical fine-mapping.Nature reviews. Genetics · 2018Review
- Functional genomics and assays of regulatory activity detect mechanisms at loci for lipid traits and coronary artery disease.Current opinion in genetics & development · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 9 institutions in 3 countries.
Maren E CannonDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Monica ZeynalzadehDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Zheng XuDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Antti J KangasComputational Medicine, Institute of Health Sciences, University of Oulu and Biocenter Oulu, 90014 Finland.
Pasi SoininenNMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, 70600 Finland.
Mika Ala-KorpelaSchool of Social and Community Medicine, University of Bristol and Medical Research Council Integrative Epidemiology Unit at the University of Bristol, BS8 1TH United Kingdom.
Mete CivelekCenter for Public Health Genomics and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904.
Aldons J LusisDepartment of Medicine, Department of Human Genetics, Molecular Biology Institute, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, 70600 Finland.
Francis S CollinsNational Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109.
Hua TangDepartment of Genetics, Stanford University, California 94305.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, 70600 Finland.
Yun LiDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 mohlke@med.unc.edu.ORCID 0000-0001-6721-153X
University of North Carolina at Chapel Hill · USUniversity of Eastern Finland · FINational Institutes of Health · USStanford University · USUniversity of Bristol · GBUniversity of California, Los Angeles · USUniversity of Michigan–Ann Arbor · USUniversity of Oulu · FIUniversity of Virginia · US
Funding
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MGENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2MGenetic Studies of Blood Cell Traits in Multi-Ethnic CohortsR01HL129132 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN, REINER, ALEXANDER P · 2016 to 2019
$2.7MFunctional genetic variants for type 2 diabetesU01DK105561 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOHLKE, KAREN L. · 2015 to 2019
$2.3MDesign and Analysis of Sequencing-based Studies for Complex Human TraitsR01HG006292 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2011 to 2015
$1.8MImputation and Analysis of Rare Variants in Admixed PopulationsR01HG006703 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2012 to 2014
$931kSystems genetics analysis of cardiometabolic trait loci in humans R00HL121172 · NHLBI · UNIVERSITY OF VIRGINIA · PI CIVELEK, METE · 2016 to 2018
$741kGenetic and metabolic effects on ANGPTL8 expression and HDL-C metabolismF31HL127984 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CANNON, MAREN ETTINGER · 2015 to 2017
$85kIntramural NIH HHS Z01 HG000024Intramural NIH HHS ZIA HG000024NHGRI NIH HHS R01 HG006292NHGRI NIH HHS R01 HG006703NHLBI NIH HHS F31 HL127984NHLBI NIH HHS R00 HL121172NHLBI NIH HHS R01 HL129132NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK105561
Abstract
Recent genome-wide association studies (GWAS) have identified variants associated with high-density lipoprotein cholesterol (HDL-C) located in or near the
Indexed as
Chromosome MappingGenetic VariationGenome-Wide Association StudyQuantitative Trait LociRegulatory Sequences, Nucleic AcidAgedAllelesAngiopoietin-Like Protein 8Angiopoietin-like ProteinsAnimalsCell LineCholesterol, HDLEnhancer Elements, GeneticGene ExpressionGenes, ReporterGenetic Association StudiesAngiopoietin-Like Protein 8Angiopoietin-like ProteinsANGPTL8 protein, humanCholesterol, HDLPeptide HormonesCholesterolComplex genetic traitsGene ExpressionGeneticsTranscription
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.