ArticleExperimental neurology2017
The differentiated networks related to essential tremor onset and its amplitude modulation after alcohol intake.
Article in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Investigating Cerebello-Cortical Networks With EEG: Advances and Future Challenges.Cerebellum (London, England) · 2026Review
- Essential tremor disrupts rhythmic brain networks during naturalistic movement.Neurobiology of disease · 2025Article
- Uncovering Cognitive Subtypes in Essential Tremor: A Data-Driven Clustering Approach in Cognitively Normal Individuals.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Upper limb intention tremor assessment: opportunities and challenges in wearable technology.Journal of neuroengineering and rehabilitation · 2024Review
- A Role for GABATremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Physiological Recordings of the Cerebellum in Movement Disorders.Cerebellum (London, England) · 2023Review
- Cerebellar α6GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Alcohol and Ganaxolone Suppress Tremor via Extra-Synaptic GABATremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Search for Novel Therapies for Essential Tremor Based on Positive Modulation of α6-Containing GABATremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Is the inferior olive central to essential tremor? Yes.International review of neurobiology · 2022Article
- Increased Purkinje Cell Complex Spike and Deep Cerebellar Nucleus Synchrony as a Potential Basis for Syndromic Essential Tremor. A Review and Synthesis of the Literature.Cerebellum (London, England) · 2021Review
- The Role of the Cerebellum in Tremor - Evidence from Neuroimaging.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Review
- Alcohol-Responsive Hyperkinetic Movement Disorders-a Mechanistic Hypothesis.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Review
- Selective loss of the GABAJournal of neurophysiology · 2020Article
- Multimodal alterations of directed connectivity profiles in patients with attention-deficit/hyperactivity disorders.Scientific reports · 2019Article
- A functional micro-electrode mapping of ventral thalamus in essential tremor.Brain : a journal of neurology · 2018Article
- Suppression of Harmaline Tremor by Activation of an Extrasynaptic GABATremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- Primary Sensorimotor Cortex Drives the Common Cortical Network for Gamma Synchronization in Voluntary Hand Movements.Frontiers in human neuroscience · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
The dysregulation of endogenous rhythms within brain networks have been implicated in a broad range of motor and non-motor pathologies. Essential tremor (ET), classically the purview of a single aberrant pacemaker, has recently become associated with network-level dysfunction across multiple brain regions. Specifically, it has been suggested that motor cortex constitutes an important node in a tremor-generating network involving the cerebellum. Yet the mechanisms by which these regions relate to tremor remain a matter of considerable debate. We sought to discriminate the contributions of cerebral and cerebellar dysregulation by combining high-density electroencephalography with subject-specific structural MRI. For that, we contrasted ET with voluntary (mimicked) tremor before and after ingestion of alcohol to regulate the tremorgenic networks. Our results demonstrate distinct loci of cortical tremor coherence, most pronounced over the sensorimotor cortices in healthy controls, but more frontal motor areas in ET-patients consistent with a heightened involvement of the supplementary motor area. We further demonstrate that the reduction in tremor amplitude associated with alcohol intake is reflected in altered cerebellar - but not cerebral - coupling with movement. Taken together, these findings implicate tremor emergence as principally associated with increases in activity within frontal motor regions, whereas modulation of the amplitude of established tremor relates to changes in cerebellar activity. These findings progress a mechanistic understanding of ET and implicate network-level vulnerabilities in the rhythmic nature of communication throughout the brain.
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Registered trials
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