ArticleParkinsonism & related disorders2017
Motor subtype changes in early Parkinson's disease.
Article in Parkinsonism & related disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Genome-Wide Meta-Analysis of Parkinson's Disease Associated Genetic Loci and Validation of Therapeutic Targets.Brain and behavior · 2025Pooled it
- Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.Journal of neurology · 2026Article
- Faster reaction times of CSF alpha-synuclein seed amplification assay predict the diffuse malignant subtype of Parkinson's disease at 10-year follow-up.Journal of Parkinson's disease · 2026Article
- Prognostic Value of Parkinson's Disease Subtypes in the LABS-PD Cohort: Functional Ability, Quality of Life and Mortality.Movement disorders clinical practice · 2026Article
- Data-driven subtyping of early Parkinson's disease via mutual cross-attention fusion of EEG and dual-task gait features.NPJ Parkinson's disease · 2026Article
- Longitudinal brain morphometry in Parkinson's disease clinical subtypes: Distinct signatures forecast behavioral change within subtypes.Parkinsonism & related disorders · 2026Article
- Feasibility study of differentiating patients with levodopa-induced dyskinesia using cerebellar gray and white matter radiomics features from 3DT1WI images.Frontiers in aging neuroscience · 2026Article
- Exploratory radiomics analysis of T1-weighted and FLAIR MRI in relation to Parkinson's disease motor subtypes.Frontiers in neurology · 2026Article
- Faster reaction times of CSF Alpha-Synuclein Seed Amplification Assay predict the Diffuse Malignant subtype of Parkinson's Disease at 10-year follow-up.medRxiv : the preprint server for health sciences · 2025Article
- Automatic differentiation of Parkinson's disease motor subtypes based on deep learning and radiomics.Frontiers in neurology · 2025Article
- Multi-modality radiomics of conventional T1 weighted and diffusion tensor imaging for differentiating Parkinson's disease motor subtypes in early-stages.Scientific reports · 2024Article
- Data-Driven Discovery of Movement-Linked Heterogeneity in Neurodegenerative Diseases.Nature machine intelligence · 2024Article
- Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data.NPJ digital medicine · 2024Article
- Classifying Tremor Dominant and Postural Instability and Gait Difficulty Subtypes of Parkinson's Disease from Full-Body Kinematics.Sensors (Basel, Switzerland) · 2023Article
- Two-year clinical progression in focal and diffuse subtypes of Parkinson's disease.NPJ Parkinson's disease · 2023Article
- The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson's disease.Therapeutic advances in neurological disorders · 2023Article
- Age Cutoff for Early-Onset Parkinson's Disease: Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson's Disease.Movement disorders clinical practice · 2022Review
- Dysautonomia and REM sleep behavior disorder contributions to progression of Parkinson's disease phenotypes.NPJ Parkinson's disease · 2022Article
- Parkinson's Disease Subtyping Using Clinical Features and Biomarkers: Literature Review and Preliminary Study of Subtype Clustering.Diagnostics (Basel, Switzerland) · 2022Review
- Prodromal Parkinson disease subtypes - key to understanding heterogeneity.Nature reviews. Neurology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
introductionDistinct motor subtypes of Parkinson's disease (PD) have been described through both clinical observation and through data-driven approaches. However, the extent to which motor subtypes change during disease progression remains unknown. Our objective was to determine motor subtypes of PD using an unsupervised clustering methodology and evaluate subtype changes with disease duration.
methodsThe Parkinson's Progression Markers Initiative database of 423 newly diagnosed PD patients was utilized to retrospectively identify unique motor subtypes through a data-driven, hierarchical correlational clustering approach. For each patient, we assigned a subtype to each motor assessment at each follow-up visit (time points) and by using published criteria. We examined changes in PD subtype with disease duration using both qualitative and quantitative methods.
resultsFive distinct motor subtypes were identified based on the motor assessment items and these included: Tremor Dominant (TD), Axial Dominant, Appendicular Dominant, Rigidity Dominant, and Postural and Instability Gait Disorder Dominant. About half of the patients had consistent subtypes at all time points. Most patients met criteria for TD subtype soon after diagnosis. For patients with inconsistent subtypes, there was an overall trend to shift away from a TD phenotype with disease duration, as shown by chi-squared test, p < 0.001, and linear regression analysis, p < 0.05.
conclusionThese results strongly suggest that classification of motor subtypes in PD can shift with increasing disease duration. Shifting subtypes is a factor that should be accounted for in clinical practice or in clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.