Evidence map›Paper›PMID 28754230›Full record

ReviewTrends in cardiovascular medicine2017

Tissue-engineered vascular grafts for congenital cardiac disease: Clinical experience and current status.

Joseph D Drews, Hideki Miyachi, Toshiharu Shinoka

Abstract readReview
In one paragraph

Review in Trends in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
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  18. Tunable Blood Shunt for Neonates With Complex Congenital Heart Defects.Frontiers in bioengineering and biotechnology · 2021
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Joseph D DrewsDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH; Tissue Engineering Program, The Heart Center, Nationwide Children׳s Hospital, Columbus, OH.
Hideki MiyachiTissue Engineering Program, The Heart Center, Nationwide Children׳s Hospital, Columbus, OH; Department of Cardiovascular Medicine, Nippon Medical School Hospital, Tokyo, Japan.
Toshiharu ShinokaDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH; Tissue Engineering Program, The Heart Center, Nationwide Children׳s Hospital, Columbus, OH. Electronic address: toshiharu.shinoka@nationwidechildrens.org.
The Ohio State University Wexner Medical Center · USNationwide Children's Hospital · US

Funding

Improving Tissue Engineered Vascular Graft Performance via Computational ModelingR01HL139796 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2018 to 2025
$6.4M
Mechanisms of Vascular Neotissue Formation In Tissue Engineered Vascular GraftsR01HL098228 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE · 2010 to 2018
$3.6M
Development of an Improved Vascular Graft for Use in Congenital Heart SurgeryR01HL128847 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE · 2016 to 2019
$2.8M
Computational Model Driven Design of Tissue Engineered Vascular GraftsR01HL128602 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2015 to 2018
$2.2M
The Ohio State University Center for Clinical and Translational ScienceTL1TR001069 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$763k
NCATS NIH HHS TL1 TR001069NHLBI NIH HHS R01 HL098228NHLBI NIH HHS R01 HL128602NHLBI NIH HHS R01 HL128847NHLBI NIH HHS R01 HL139796
6 · The paper itself

Abstract

Congenital heart disease is a leading cause of death in the newborn period, and man-made grafts currently used for reconstruction are associated with multiple complications. Tissue engineering can provide an alternative source of vascular tissue in congenital cardiac surgery. Clinical trials have been successful overall, but the most frequent complication is graft stenosis. Recent studies in animal models have indicated the important role of the recipient׳s immune response in neotissue formation, and that modulating the immune response can reduce the incidence of stenosis.

Indexed as

BioprosthesisBlood Vessel ProsthesisTissue ScaffoldsAdolescentAdultAnimalsBlood Vessel Prosthesis ImplantationCell TransplantationChildChild, PreschoolFemaleGraft Occlusion, VascularHeart Defects, CongenitalHumansInfantMaleBone marrow-derived mononuclear cellsCongenital cardiac diseaseFontanSurgeryTissue-engineered vascular graftTissue engineering

Identifiers

PMID28754230
PMCPMC5634923
OpenAlexW2723476276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.