Evidence map›Paper›PMID 28754123›Full record

ArticleGenome medicine2017

Post-mortem molecular profiling of three psychiatric disorders.

Ryne C Ramaker, Kevin M Bowling, Brittany N Lasseigne, Megan H Hagenauer, Andrew A Hardigan, Nicholas S Davis, Jason Gertz, Preston M Cartagena, David M Walsh, Marquis P Vawter and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 11 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 11 syntheses or guidelines pooled it, 211 citations in OpenAlex.

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  12. The role ofEpigenetics · 2026
    Review
  13. Article
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  16. Article
  17. Alpha psychiatry · 2026
    Article
  18. Article
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 1 country.

Ryne C RamakerHudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA.
Kevin M BowlingHudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA.
Brittany N LasseigneHudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA.
Megan H HagenauerMental Health Research Institute, University of Michigan, Ann Arbor, MI, USA.
Andrew A HardiganHudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA.
Nicholas S DavisHudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA.
Jason GertzHudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA.
Preston M CartagenaDepartment of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA.
David M WalshDepartment of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA.
Marquis P VawterDepartment of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA.
Edward G Jones
Alan F SchatzbergDepartment of Psychiatry, Stanford University School of Medicine, Stanford, CA, USA.
Jack D BarchasPsychiatry, Weill Cornell Medical College, New York, NY, USA.
Stanley J WatsonMental Health Research Institute, University of Michigan, Ann Arbor, MI, USA.
Blynn G BunneyDepartment of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA.
Huda AkilMental Health Research Institute, University of Michigan, Ann Arbor, MI, USA.
William E BunneyDepartment of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA.
Jun Z LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Sara J CooperHudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA.
Richard M MyersHudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, AL, 35806, USA. rmyers@hudsonalpha.org.
HudsonAlpha Institute for Biotechnology · USUniversity of California, Irvine · USUniversity of Michigan–Ann Arbor · USCornell University · USStanford University · USUniversity of Alabama at Birmingham · USUniversity of Utah · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Mitochondrial Dysfunction In SchizophreniaR01MH085801 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAWTER, MARQUIS PHILIP · 2009 to 2020
$5.0M
Multidimensional Analysis of Synaptic Dysfunction in SchizophreniaR21MH113177 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMON, AGENOR, VAWTER, MARQUIS PHILIP · 2017 to 2018
$425k
NIGMS NIH HHS T32 GM008361NIMH NIH HHS R01 MH085801
6 · The paper itself

Abstract

backgroundPsychiatric disorders are multigenic diseases with complex etiology that contribute significantly to human morbidity and mortality. Although clinically distinct, several disorders share many symptoms, suggesting common underlying molecular changes exist that may implicate important regulators of pathogenesis and provide new therapeutic targets.

methodsWe performed RNA sequencing on tissue from the anterior cingulate cortex, dorsolateral prefrontal cortex, and nucleus accumbens from three groups of 24 patients each diagnosed with schizophrenia, bipolar disorder, or major depressive disorder, and from 24 control subjects. We identified differentially expressed genes and validated the results in an independent cohort. Anterior cingulate cortex samples were also subjected to metabolomic analysis. ChIP-seq data were used to characterize binding of the transcription factor EGR1.

resultsWe compared molecular signatures across the three brain regions and disorders in the transcriptomes of post-mortem human brain samples. The most significant disease-related differences were in the anterior cingulate cortex of schizophrenia samples compared to controls. Transcriptional changes were assessed in an independent cohort, revealing the transcription factor EGR1 as significantly down-regulated in both cohorts and as a potential regulator of broader transcription changes observed in schizophrenia patients. Additionally, broad down-regulation of genes specific to neurons and concordant up-regulation of genes specific to astrocytes was observed in schizophrenia and bipolar disorder patients relative to controls. Metabolomic profiling identified disruption of GABA levels in schizophrenia patients.

conclusionsWe provide a comprehensive post-mortem transcriptome profile of three psychiatric disorders across three brain regions. We highlight a high-confidence set of independently validated genes differentially expressed between schizophrenia and control patients in the anterior cingulate cortex and integrate transcriptional changes with untargeted metabolite profiling.

Indexed as

TranscriptomeAutopsyBipolar DisorderBrainChromatin ImmunoprecipitationEarly Growth Response Protein 1FemaleHumansMajor Depressive DisorderMaleMetabolomicsSchizophreniaSequence Analysis, RNAEarly Growth Response Protein 1EGR1 protein, humanBipolar disorderEGR1Major depressive disorderMetabolomicsRNA sequencingSchizophrenia

Identifiers

PMID28754123
PMCPMC5534072
OpenAlexW2953330634

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.