ArticleBMC neurology2017
Peripheral blood lymphocytes immunophenotyping predicts disease activity in clinically isolated syndrome patients.
Article in BMC neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association between peripheral blood immunological status and intrathecal inflammatory markers differentiate multiple sclerosis clinical phenotypes.Acta neurologica Belgica · 2024Article
- Analysis of cerebrospinal fluid cells by flow cytometry: Comparison to conventional cytology.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023Article
- Cytokine Secretion Dynamics of Isolated PBMC after Cladribine Exposure in RRMS Patients.International journal of molecular sciences · 2022Article
- Alteration of circulating unconventional T cells in cerebral ischemia: an observational study.Scientific reports · 2022Observational
- Clinical and imaging analysis to evaluate the response of patients with anti-DPPX encephalitis to immunotherapy.BMC neurology · 2022Article
- Dynamic changes of peripheral blood lymphocyte subsets in acute ischemic stroke and prognostic value.Brain and behavior · 2021Article
- Effects of cladribine tablets on lymphocyte subsets in patients with multiple sclerosis: an extended analysis of surface markers.Therapeutic advances in neurological disorders · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinically isolated syndrome (CIS) represents first neurological symptoms suggestive of demyelinating lesion in the central nervous system (CNS). Currently, there are no sufficient immunological or genetic markers predicting relapse and disability progression, nor there is evidence of the efficacy of registered disease modifying treatments (DMTs), such as intramuscular interferon beta1a. The aim of the study is to evaluate immunological predictors of a relapse or disability progression.
methodsOne hundred and eighty one patients with CIS were treated with interferon beta1a and followed over the period of 4 years. Lymphocyte subsets were analyzed by flow cytometry. A Kaplan-Meier estimator of survival probability was used to analyze prognosis. For statistical assessment only individual differences between baseline values and values at the time of relapse or confirmed disability progression were analysed.
resultsHigher levels of B lymphocytes predicted relapse-free status. On the other hand, a decrease of the naïve subset of cells (CD45RA+ in CD4+) after 12, 24, and 36 months of follow-up were associated with an increased risk of confirmed disability progression.
conclusionOur data suggest that the quantification of lymphocyte subsets in patients after the first demyelinating event suggestive of MS may be an important biomarker.
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