Evidence map›Paper›PMID 28753992›Full record

ReviewViruses2017

Applicability of Metal Nanoparticles in the Detection and Monitoring of Hepatitis B Virus Infection.

Maxim Shevtsov, Lili Zhao, Ulrike Protzer, Maarten A A van de Klundert

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Maxim ShevtsovKlinikum rechts der Isar, Technischen Universität München (TUM), Ismaniger Str. 22, 81675 Munich, Germany. maxim.shevtsov@tum.de.
Lili ZhaoInstitute of Virology, Technische Universität München/Helmholtz Zentrum München-German Center for Environmental Health, Trogerstr. 30, 81675 Munich, Germany. lili.zhao@tum.de.
Ulrike ProtzerInstitute of Virology, Technische Universität München/Helmholtz Zentrum München-German Center for Environmental Health, Trogerstr. 30, 81675 Munich, Germany. protzer@tum.de.
Maarten A A van de KlundertInstitute of Virology, Technische Universität München/Helmholtz Zentrum München-German Center for Environmental Health, Trogerstr. 30, 81675 Munich, Germany. maarten.van-de-klundert@tum.de.
Helmholtz Zentrum München · DETUM Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic infection with the hepatitis B virus (HBV) can lead to liver failure and can cause liver cirrhosis and hepatocellular carcinoma (HCC). Reliable means for detecting and monitoring HBV infection are essential to identify patients in need of therapy and to prevent HBV transmission. Nanomaterials with defined electrical, optical, and mechanical properties have been developed to detect and quantify viral antigens. In this review, we discuss the challenges in applying nanoparticles to HBV antigen detection and in realizing the bio-analytical potential of such nanoparticles. We discuss recent developments in generating detection platforms based on gold and iron oxide nanoparticles. Such platforms increase biological material detection efficiency by the targeted capture and concentration of HBV antigens, but the unique properties of nanoparticles can also be exploited for direct, sensitive, and specific antigen detection. We discuss several studies that show that nanomaterial-based platforms enable ultrasensitive HBV antigen detection.

Indexed as

Biosensing TechniquesMetal NanoparticlesCarcinoma, HepatocellularDNA, ViralGoldHepatitis BHepatitis B Surface AntigensHepatitis B virusHumansLiver CirrhosisLiver NeoplasmsMagnetite NanoparticlesDNA, ViralGoldHepatitis B Surface AntigensMagnetite Nanoparticlesbiosensorgold nanoparticleshepatitis Bmagnetic nanoparticlesvirus

Identifiers

PMID28753992
PMCPMC5537685
OpenAlexW2738986671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.