Evidence map›Paper›PMID 28753942›Full record

ArticleNutrients2017

Quercetin and Green Tea Extract Supplementation Downregulates Genes Related to Tissue Inflammatory Responses to a 12-Week High Fat-Diet in Mice.

Lynn Cialdella-Kam, Sujoy Ghosh, Mary Pat Meaney, Amy M Knab, R Andrew Shanely, David C Nieman

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Nutrients Lowering Obesity-Linked Chemokines Blamable for Metastasis.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Applications of Tea (Molecules (Basel, Switzerland) · 2019
    Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Lynn Cialdella-KamDepartment of Nutrition, School of Medicine-WG 48, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. lynn.kam@case.edu.
Sujoy GhoshProgram in Cardiovascular & Metabolic Diseases and Center for Computational Biology, Duke NUS Medical School, 8 College Road, Singapore 169857, Singapore. sujoy.ghosh@duke-nus.edu.sg.
Mary Pat MeaneyDepartment of Exercise Physiology, School of Health Sciences, Winston-Salem State University, 601 S. Martin Luther King Jr. Drive, Winston-Salem, NC 27110, USA. meaneyMP@wssu.edu.
Amy M KnabLevine Center for Health and Wellness, Queens University of Charlotte, 1900 Selwyn Avenue, Charlotte, NC 28274, USA. knaba@queens.edu.
R Andrew ShanelyDepartment of Health & Exercise Science, Appalachian State University, ASU Box 32071, 111 Rivers Street, 050 Convocation Center, Boone, NC 28608, USA. shanelyra@appstate.edu.
David C NiemanHuman Performance Laboratory, North Carolina Research Campus, Appalachian State University, 600 Laureate Way, Kannapolis, NC 28081, USA. niemandc@appstate.edu.
Appalachian State University · USCase Western Reserve University · USDuke-NUS Medical School · SGQueens University of Charlotte · USWinston-Salem State University · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

Quercetin (Q) and green tea extract (E) are reported to counter insulin resistance and inflammation and favorably alter fat metabolism. We investigated whether a mixture of E + Q (EQ) could synergistically influence metabolic and inflammation endpoints in a high-fat diet (HFD) fed to mice. Male C57BL/6 mice (

Indexed as

AdiposityAnimalsBody Mass IndexBody WeightCatechinCytokinesDietary SupplementsDiet, High-FatEndpoint DeterminationGene Expression RegulationGlucose Tolerance TestInflammationInsulin ResistanceLipid MetabolismMaleMiceCatechinCytokinesepigallocatechin gallatePlant ExtractsQuercetinTeacytokinesfat metabolismflavonoidsimmune functioninflammationinsulin resistancemetabolic syndromeobesityphytochemicals

Identifiers

PMID28753942
PMCPMC5537887
OpenAlexW2738906868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.