Evidence map›Paper›PMID 28753927›Full record

ArticleNutrients2017

Self-Reported Non-Celiac Wheat Sensitivity in High School Students: Demographic and Clinical Characteristics.

Antonio Carroccio, Ornella Giambalvo, Francesco La Blasca, Rosario Iacobucci, Alberto D'Alcamo, Pasquale Mansueto

3 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04769180 completednot on this map

Extraintestinal Manifestations in Non Celiac Wheat Sensitivity

TypeobservationalSponsorUniversity of PalermoRan2000 to 2021Enrolled200ConditionsNon-celiac Gluten SensitivityArmsEvaluation of extraintestinal manifestations
NCT05644782 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Role of Gut-skin Axis in Psoriasis: a Randomized Placebo-controlled Dietary Approach to Assess Clinical Efficacy in Mild-to-moderate Psoriasis

TypeinterventionalSponsorUniversity of PalermoRan2025 to 2027Enrolled82ConditionsPsoriasis, Gluten SensitivityArmsOpen wheat challenge, Placebo challenge
NCT05644795 nacompletednot on this mapstarted 2023, after this paper: background citation

Efficacy of a Wheat-free Diet in Autoimmune Diseases: a Pilot Therapeutic Study in Sjogren's Disease

TypeinterventionalSponsorUniversity of PalermoRan2023 to 2026Enrolled30ConditionsSjogren's Syndrome, Non-celiac Gluten SensitivityArmsWheat/milk free diet (W/MFD) group, Rice/turkey free diet (R/TFD) group
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

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  14. Non-Celiac Gluten Sensitivity: An Update.Medicina (Kaunas, Lithuania) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Antonio CarroccioInternal Medicine, Dipartimento di Biologia e Medicina Interna e Specialistica, University of Palermo, 90133 Palermo, Italy. antonio.carroccio@unipa.it.
Ornella GiambalvoDepartment of Economics, Management and Statistics, University of Palermo, 90127 Palermo, Italy. ornella.giambalvo@unipa.it.
Francesco La BlascaDipartimento di Biologia e Medicina Interna e Specialistica, Division of Internal Medicine, Policlinico University Hospital, 90127 Palermo, Italy. francescolablasca@gmail.com.
Rosario IacobucciDipartimento di Biologia e Medicina Interna e Specialistica, Division of Internal Medicine, Policlinico University Hospital, 90127 Palermo, Italy. iacobuccirosario@gmail.com.
Alberto D'AlcamoDipartimento di Biologia e Medicina Interna e Specialistica, Division of Internal Medicine, Policlinico University Hospital, 90127 Palermo, Italy. adalcamo@hotmail.it.
Pasquale MansuetoDipartimento di Biologia e Medicina Interna e Specialistica, Division of Internal Medicine, Policlinico University Hospital, 90127 Palermo, Italy. pasquale.mansueto@unipa.it.
University of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-Celiac Wheat Sensitivity (NCWS) has recently been included among the gluten-related disorders. As no biomarkers of this disease exist, its frequency has been estimated based on self-reported symptoms, but to date no data are available about self-reported NCWS in teenagers.

aimTo explore the prevalence of self-reported NCWS in a group of high school students and to study their demographic and clinical characteristics.

methodsThe study was performed between April 2015 and January 2016 in two high schools of a coastal town in the south of Sicily (Italy). A total of 555 students (mean age 17 years, 191 male, 364 female) completed a modified validated questionnaire for self-reported NCWS. The subjects who self-reported NCWS were then compared with all the others.

resultsSeven individuals (1.26%) had an established diagnosis of CD. The prevalence of self-reported NCWS was 12.2%, and 2.9% were following a gluten-free diet (GFD). Only 15 out of 68 (23%) NCWS self-reporters had consulted a doctor for this problem and only nine (14%) had undergone serological tests for celiac disease. The NCWS self-reporters very often had IBS symptoms (44%).

conclusionsSelf-reported NCWS was found to be common in teenagers, with a frequency of 12.2%; the frequency of GFD use was 2.9%, which was much higher than the percentage of known CD in the same population (1.26%). A greater awareness of the possible implications on the part of the subjects involved, and a more thorough medical approach to the study of self-reported wheat-induced symptoms are required.

Indexed as

Self ReportAdolescentCase-Control StudiesCeliac DiseaseDiet, Gluten-FreeFemaleGlutensHumansMaleSicilyStudentsTriticumWheat HypersensitivityGlutensepidemiologyfood allergyIBSnon-celiac gluten-sensitivityprevalenceself-reported non-celiac wheat sensitivityteenagers

Identifiers

PMID28753927
PMCPMC5537885
OpenAlexW2737528652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.