Evidence map›Paper›PMID 28753389›Full record

ArticleRadiology2017

Feasibility of Dose-reduced Chest CT with Photon-counting Detectors: Initial Results in Humans.

Rolf Symons, Amir Pourmorteza, Veit Sandfort, Mark A Ahlman, Tracy Cropper, Marissa Mallek, Steffen Kappler, Stefan Ulzheimer, Mahadevappa Mahesh, Elizabeth C Jones and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03878134 (Translational Development of Photon-Counting CT Imaging), which is not on this map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03878134 nacompletednot on this mapstarted 2019, after this paper: background citation

Translational Development of Photon-Counting CT Imaging

TypeinterventionalSponsorNational Institutes of Health Clinical Center (CC)Ran2019 to 2022Enrolled67ConditionsCancer, Inflammatory Disease, Vascular Diseases, Metabolic Bone DiseaseArmsPHOTON COUNTING CT Scanner
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 184 citations in OpenAlex.

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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Rolf SymonsFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).ORCID 0000-0001-7889-6773
Amir PourmortezaFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Veit SandfortFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Mark A AhlmanFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Tracy CropperFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Marissa MallekFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Steffen KapplerFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Stefan UlzheimerFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Mahadevappa MaheshFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Elizabeth C JonesFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Ashkan A MalayeriFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
Les R FolioFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).
David A BluemkeFrom the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Bethesda, MD 20892 (R.S., A.P., V.S., M.A.A., T.C., M. Mallek, E.C.J., A.A.M., L.R.F., D.A.B.); Siemens Healthcare, Forchheim, Germany (S.K., S.U.); and Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (M. Mahesh).ORCID 0000-0002-8323-8086
Johns Hopkins University · US

Funding

Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
Molecular Biomedical Imaging Laboratory (CC)ZIACL090019 · CLC · CLINICAL CENTER · PI JONES, ELIZABETH C. · 2010 to 2017
$0k
Intramural NIH HHS ZIA CL090019Intramural NIH HHS ZIA EB000072
6 · The paper itself

Abstract

Purpose To investigate whether photon-counting detector (PCD) technology can improve dose-reduced chest computed tomography (CT) image quality compared with that attained with conventional energy-integrating detector (EID) technology in vivo. Materials and Methods This was a HIPAA-compliant institutional review board-approved study, with informed consent from patients. Dose-reduced spiral unenhanced lung EID and PCD CT examinations were performed in 30 asymptomatic volunteers in accordance with manufacturer-recommended guidelines for CT lung cancer screening (120-kVp tube voltage, 20-mAs reference tube current-time product for both detectors). Quantitative analysis of images included measurement of mean attenuation, noise power spectrum (NPS), and lung nodule contrast-to-noise ratio (CNR). Images were qualitatively analyzed by three radiologists blinded to detector type. Reproducibility was assessed with the intraclass correlation coefficient (ICC). McNemar, paired t, and Wilcoxon signed-rank tests were used to compare image quality. Results Thirty study subjects were evaluated (mean age, 55.0 years ± 8.7 [standard deviation]; 14 men). Of these patients, 10 had a normal body mass index (BMI) (BMI range, 18.5-24.9 kg/m

Indexed as

AgedEquipment DesignEquipment Failure AnalysisFeasibility StudiesHumansMiddle AgedPhotometryPilot ProjectsRadiation DosageRadiation ExposureRadiation ProtectionRadiography, ThoracicReproducibility of ResultsSensitivity and SpecificityTomography, X-Ray Computed

Identifiers

PMID28753389
PMCPMC5708286
OpenAlexW2740188036

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.