ArticleAmerican journal of respiratory and critical care medicine2017
Occupational Exposures and Subclinical Interstitial Lung Disease. The MESA (Multi-Ethnic Study of Atherosclerosis) Air and Lung Studies.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
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- Clinical outcomes of interstitial lung abnormalities: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
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- [Evaluation and clinical management of interstitial lung abnormalities : Position paper of the Austrian Society of Pneumology (ÖGP) and the Austrian Radiological Society (ÖRG) 2026].Wiener klinische Wochenschrift · 2026Review
- Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases.Tuberculosis and respiratory diseases · 2025Article
- Interstitial Lung Abnormality in Health Screening Examinees: Prevalence, Outcomes, and Risk Factors.Journal of Korean medical science · 2025Article
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- Integrating CT radiomics and clinical features using machine learning to predict post-COVID pulmonary fibrosis.Respiratory research · 2025Article
- A Comprehensive Review of Interstitial Lung Abnormalities.Respirology (Carlton, Vic.) · 2025Review
- Current perspectives on interstitial lung abnormalities.The Korean journal of internal medicine · 2025Review
- Interstitial Lung Abnormalities: Unraveling the Journey from Incidental Discovery to Clinical Significance.Diagnostics (Basel, Switzerland) · 2025Review
- Air Pollution Exposure and Interstitial Lung Features in SPIROMICS Participants with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2024Article
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- Scoping review of exposure questionnaires and surveys in interstitial lung disease.BMJ open respiratory research · 2024Article
- Current Landscape and Future Directions of Patient Education in Adults with Interstitial Lung Disease.ATS scholar · 2024Review
- Structural and social determinants of health: The multi-ethnic study of atherosclerosis.PloS one · 2024Article
- Club Cells-A Guardian against Occupational Hazards.Biomedicines · 2023Review
- Approach to Clinical Trials for the Prevention of Pulmonary Fibrosis.Annals of the American Thoracic Society · 2023Article
- Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
rationaleThe impact of a broad range of occupational exposures on subclinical interstitial lung disease (ILD) has not been studied.
objectivesTo determine whether occupational exposures to vapors, gas, dust, and fumes (VGDF) are associated with high-attenuation areas (HAA) and interstitial lung abnormalities (ILA), which are quantitative and qualitative computed tomography (CT)-based measurements of subclinical ILD, respectively.
methodsWe performed analyses of participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a population-based cohort aged 45-84 years at recruitment. HAA was measured at baseline and on serial cardiac CT scans in 5,702 participants. ILA was ascertained in a subset of 2,312 participants who underwent full-lung CT scanning at 10-year follow-up. Occupational exposures were assessed by self-reported VGDF exposure and by job-exposure matrix (JEM). Linear mixed models and logistic regression were used to determine whether occupational exposures were associated with log-transformed HAA and ILA. Models were adjusted for age, sex, race/ethnicity, education, employment status, tobacco use, and scanner technology. MEASUREMENTS AND MAIN
resultsEach JEM score increment in VGDF exposure was associated with 2.64% greater HAA (95% confidence interval [CI], 1.23-4.19%). Self-reported vapors/gas exposure was associated with an increased odds of ILA among those currently employed (1.76-fold; 95% CI, 1.09-2.84) and those less than 65 years old (1.97-fold; 95% CI, 1.16-3.35). There was no consistent evidence that occupational exposures were associated with progression of HAA over the follow-up period.
conclusionsJEM-assigned and self-reported exposures to VGDF were associated with measurements of subclinical ILD in community-dwelling adults.
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