Evidence map›Paper›PMID 28753028›Full record

ArticleOrganic letters2017

General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor.

Xiang Fei, Megan E Zavorka, Guillaume Malik, Christopher M Connelly, Richard G MacDonald, David B Berkowitz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiang FeiDepartment of Chemistry, University of Nebraska , Lincoln, Nebraska 68588-0304, United States.
Megan E ZavorkaDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center , Omaha, Nebraska 68198-5870, United States.
Guillaume MalikDepartment of Chemistry, University of Nebraska , Lincoln, Nebraska 68588-0304, United States.
Christopher M ConnellyDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center , Omaha, Nebraska 68198-5870, United States.
Richard G MacDonaldDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center , Omaha, Nebraska 68198-5870, United States.
David B BerkowitzDepartment of Chemistry, University of Nebraska , Lincoln, Nebraska 68588-0304, United States.ORCID 0000-0001-7550-0112

Funding

EXTRAMURAL RES FACILITIES CONSTRC06RR016544 · NCRR · UNIVERSITY OF NEBRASKA LINCOLN · PI PAUL, PREM S · 2001 to 2001
$2.0M
Molecular Dissection of IGF2R Growth Suppressor ActivityR01CA091885 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MACDONALD, RICHARD G. · 2001 to 2004
$659k
IGF-II-Based Approach to Therapy for Pancreatic CancerR21CA198292 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MACDONALD, RICHARD G. · 2015 to 2016
$359k
NCI NIH HHS R01 CA091885NCI NIH HHS R21 CA198292NCRR NIH HHS C06 RR016544
6 · The paper itself

Abstract

A generalized strategy is presented for the rapid assembly of a set of bivalent ligands with a variety of linking functionalities from a common monomer. Herein, an array of phosphatase-inert mannose-6-phosphonate-presenting ligands for the cation-independent-mannose 6-phosphate receptor (CI-MPR) is constructed. Receptor binding affinity varies with linking functionality-the simple amide and 1,5-triazole(tetrazole) being preferred over the 1,4-triazole. This approach is expected to find application across chemical biology, particularly in glycoscience, wherein multivalency often governs molecular recognition.

Indexed as

AmidesCationsCycloaddition ReactionHydrogen BondingLigandsMolecular StructureProtein Array AnalysisProtein BindingReceptor, IGF Type 2TriazolesAmidesCationsLigandsReceptor, IGF Type 2Triazoles

Identifiers

PMID28753028
PMCPMC6208139

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.