ArticleEnvironmental microbiology2017
Systematic genetic dissection of chitin degradation and uptake in Vibrio cholerae.
Article in Environmental microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Temperate phages limit their own propagation under spatial constraint in biofilms on chitin.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine.Nature communications · 2026Article
- Predator-prey dynamics of Vibrio cholerae on chitin suggest an alternative mode of biofilm formation in marine snow conditions.The ISME journal · 2026Article
- Isolation and characterization of chitinolytic fast-growing bacteria from marine environment in Vietnam.Journal, genetic engineering & biotechnology · 2025Article
- Article
- Streptomyces venezuelae uses secreted chitinases and a designated ABC transporter to support the competitive saprophytic catabolism of chitin.PLoS biology · 2025Article
- ChiVariARIBA: a modular, editable workflow and database for characterising chitin gene variation inMicrobial genomics · 2025Article
- Decoding microbiome responses to quarantine potato wart disease: first insights into suppression and biocontrol by full-length 16S rRNA gene profiling and functional prediction.Frontiers in plant science · 2025Article
- Discovery of Vibrio cholerae in Urban Sewage in Copenhagen, Denmark.Microbial ecology · 2024Article
- Chitin degradation by Synechococcus WH7803.Scientific reports · 2023Article
- Inherited chitinases enable sustained growth and rapid dispersal of bacteria from chitin particles.Nature microbiology · 2023Article
- The molecular mechanism for carbon catabolite repression of the chitin response in Vibrio cholerae.PLoS genetics · 2023Article
- The potential of degrading natural chitinous wastes to oligosaccharides by chitinolytic enzymes from two Talaromyces sp. isolated from rotten insects (Hermetia illucens) under solid state fermentation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Genomic analysis and chitinase characterization ofFrontiers in microbiology · 2023Article
- Biodegradation and Prospect of Polysaccharide from Crustaceans.Marine drugs · 2022Review
- The Fish Pathogen Aliivibrio salmonicida LFI1238 Can Degrade and Metabolize Chitin despite Gene Disruption in the Chitinolytic Pathway.Applied and environmental microbiology · 2021Article
- Bacterial predation transforms the landscape and community assembly of biofilms.Current biology : CB · 2021Article
- Article
- Chitin Degradation Machinery and Secondary Metabolite Profiles in the Marine BacteriumMarine drugs · 2021Article
- Structural characterization of two solute-binding proteins forJournal of structural biology: X · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vibrio cholerae is a natural resident of the aquatic environment, where a common nutrient is the chitinous exoskeletons of microscopic crustaceans. Chitin utilization requires chitinases, which degrade this insoluble polymer into soluble chitin oligosaccharides. These oligosaccharides also serve as an inducing cue for natural transformation in Vibrio species. There are 7 predicted endochitinase-like genes in the V. cholerae genome. Here, we systematically dissect the contribution of each gene to growth on chitin as well as induction of natural transformation. Specifically, we created a strain that lacks all 7 putative chitinases and from this strain, generated a panel of strains where each expresses a single chitinase. We also generated expression plasmids to ectopically express all 7 chitinases in our chitinase deficient strain. Through this analysis, we found that low levels of chitinase activity are sufficient for natural transformation, while growth on insoluble chitin as a sole carbon source requires more robust and concerted chitinase activity. We also assessed the role that the three uptake systems for the chitin degradation products GlcNAc, (GlcNAc)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.