Evidence map›Paper›PMID 28752859›Full record

ArticleCancer gene therapy2017

MicroRNA-140-5p inhibits invasion and angiogenesis through targeting VEGF-A in breast cancer.

Y Lu, T Qin, J Li, L Wang, Q Zhang, Z Jiang, J Mao

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer gene therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

  1. Trial
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  12. BAP31 Promotes Angiogenesis via Galectin-3 Upregulation in Neuroblastoma.International journal of molecular sciences · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA.International journal of molecular sciences · 2023
    Review
  17. Review
  18. Article
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Y LuTeaching Laboratory of Morphology, Dalian Medical University, Dalian, China.
T QinDepartment of Pathology, Dalian Medical University, Dalian, China.
J LiDepartment of Pathology, Dalian Medical University, Dalian, China.
L WangDepartment of Pathology, Dalian Medical University, Dalian, China.
Q ZhangDepartment of Pathology, Dalian Medical University, Dalian, China.
Z JiangDepartment of Pathology, Dalian Medical University, Dalian, China.
J MaoDepartment of Pathology, Dalian Medical University, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) have been proven to be involved in cell metastasis and angiogenesis by interaction with the target mRNAs. Evidence has been confirmed that miR-140-5p is a tumor suppressor in human cancers such as breast cancer. However, the potential molecular mechanism of miR-140-5p in breast cancer invasion and angiogenesis is still poorly understood. According to our study, we reported that miR-140-5p inhibited the tumor invasion and angiogenesis of breast cancer cells both in vitro and in vivo by targeting VEGF-A. The mRNA amount of miR-140-5p was decreased in the breast cancer clinical samples and breast cancer with metastasis compared with the corresponding adjacent normal tissues and cancer without metastasis. MiR-140-5p mimics and a negative control were transfected into human MCF-7 and MDA-MB-231 cells. Transwell chambers were used to detect the invasive ability of the cells, and the angiogenic ability was assessed by tube-formation assay. The markers of invasion and angiogenesis, VEGF-A, CD31 and MMP-9, were detected by using immunohistochemistry and western blot analysis in vivo. VEGF-A was verified as a possible target gene of miR-140-5p, and corroborated by dual-luciferase reporter and ELISA. Taken together, the study elucidates the molecular mechanisms by which miR-140-5p inhibits breast cancer metastasis and angiogenesis, and provides a potent evidence for the development of a novel microRNA-targeting anticancer strategy for breast cancer patients.

Indexed as

Gene Expression RegulationBreast NeoplasmsFemaleHumansMCF-7 CellsMicroRNAsNeoplasm InvasivenessNeoplasm ProteinsNeovascularization, PathologicRNA, NeoplasmVascular Endothelial Growth Factor AMicroRNAsMirn140 microRNA, humanNeoplasm ProteinsRNA, NeoplasmVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID28752859
PMCPMC5668497

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.