Evidence map›Paper›PMID 28752857›Full record

ReviewNature reviews. Neurology2017

Insights into the mechanisms of deep brain stimulation.

Keyoumars Ashkan, Priya Rogers, Hagai Bergman, Ismail Ughratdar

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05284526 (Prospective Study Evaluating the EEG Recordings and Analysis in Parkinson's Patients), which is not on this map. Cited by 177 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 8 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05284526 nacompletednot on this mapstarted 2022, after this paper: background citation

Prospective Study Evaluating the EEG Recordings and Analysis in Parkinson's Patients: Towards Adaptive Deep Brain Stimulation by Machine Learning

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2022 to 2023Enrolled30ConditionsParkinson DiseaseArmselectroencephalogram (EEG) of control and parkinsonian subjects during the preparation and execution of movements
3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 8 syntheses or guidelines pooled it, 362 citations in OpenAlex.

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117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Keyoumars AshkanKing's College Hospital, Department of Neurosurgery, Denmark Hill, London SE5 9RS, UK.
Priya RogersGuy's, King's and St Thomas' School of Medicine, Great Maze Pond, London SE1 9RT, UK.
Hagai BergmanThe Hebrew University of Jerusalem, Department of Medical Neurobiology, Hadassah Medical School, P.O.B. 12272, Jerusalem 91120, Israel.
Ismail UghratdarQueen Elizabeth Hospital Birmingham, Department of Neurosurgery, Mindelsohn Way, Birmingham B15 2TH, UK.
King's College Hospital · GBHebrew University of Jerusalem · ILQueen Elizabeth Hospital Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite long-term and widespread use of deep brain stimulation (DBS) in a variety of neurological conditions, the underlying mechanisms of action have been elusive. Growing evidence suggests that DBS acts through multimodal mechanisms that are not limited to inhibition and excitation of basal ganglia circuits. DBS also seems to act over variable time spans - for example, the effects on tremor are immediate, whereas the effects on dystonia emerge over several weeks - suggesting that large networks are targeted. Studies reviewing the use of DBS in pain and obsessive-compulsive disorder have demonstrated direct involvement of axonal fibres rather than grey matter. In this Review, we draw on clinical and experimental data to examine the various hypotheses that have been put forward to explain the effects of DBS. In agreement with several other experts, we suggest that the term 'deep brain stimulation' warrants modification. A potentially more accurate term is 'deep brain neuromodulation', as the mode of action spans an array of therapeutic effects over a variable period of time, and is not just limited to 'stimulation' of the basal ganglia brain centres. Terms such as 'electrical neuro-network modulation' may be useful for applications in which deep brain structures are not the primary target.

Indexed as

Deep Brain StimulationAnimalsBasal GangliaCerebral CortexHumansMental DisordersNerve NetNeuronal PlasticityNeuroprotectionParkinson DiseaseProcedural Pain

Identifiers

PMID28752857
OpenAlexW2741917192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.