Trial reportEye (London, England)2018
An international comparison of retinopathy of prematurity grading performance within the Benefits of Oxygen Saturation Targeting II trials.
Trial report in Eye (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Application of a Quantitative Vascular Severity Score in Retinopathy of Prematurity in the United States and India: New Insights Into Disease Epidemiology and Pathophysiology.American journal of ophthalmology · 2026Article
- P Score: A Reference Image-Based Clinical Grading Scale for Vascular Change in Retinopathy of Prematurity.Ophthalmology · 2024Article
- Reduction of pathological retinal neovascularization, vessel obliteration, and artery tortuosity by PEDF protein in an oxygen-induced ischemic retinopathy rat model.FASEB bioAdvances · 2024Article
- Retinal blood flow velocities in infants with retinopathy of prematurity after intravitreal administration of bevacizumab.European journal of ophthalmology · 2024Observational
- Multicenter Validation of Deep Learning Algorithm ROP.AI for the Automated Diagnosis of Plus Disease in ROP.Translational vision science & technology · 2023Article
- Development and validation of an artificial intelligence based screening tool for detection of retinopathy of prematurity in a South Indian population.Frontiers in pediatrics · 2023Article
- Evaluation of an Artificial Intelligence System for Retinopathy of Prematurity Screening in Nepal and Mongolia.Ophthalmology science · 2022Article
- Federated Learning in Ocular Imaging: Current Progress and Future Direction.Diagnostics (Basel, Switzerland) · 2022Review
- ADS-Net: attention-awareness and deep supervision based network for automatic detection of retinopathy of prematurity.Biomedical optics express · 2022Article
- Artificial Intelligence for Retinopathy of Prematurity: Validation of a Vascular Severity Scale against International Expert Diagnosis.Ophthalmology · 2022Article
- Retinopathy of prematurity classification updates: possible implications for treatment.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2022Article
- International Classification of Retinopathy of Prematurity, Third Edition.Ophthalmology · 2021Review
- Evaluation of a Deep Learning-Derived Quantitative Retinopathy of Prematurity Severity Scale.Ophthalmology · 2021Article
- Variability in Plus Disease Identified Using a Deep Learning-Based Retinopathy of Prematurity Severity Scale.Ophthalmology. Retina · 2020Article
- Aggressive Posterior Retinopathy of Prematurity: Clinical and Quantitative Imaging Features in a Large North American Cohort.Ophthalmology · 2020Article
- Practice Guidelines for Ocular Telehealth-Diabetic Retinopathy, Third Edition.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2020Article
- Telemedicine for Retinopathy of Prematurity.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2020Review
- Artificial Intelligence in Retinopathy of Prematurity Diagnosis.Translational vision science & technology · 2020Review
- Deep Learning Algorithm for Automated Diagnosis of Retinopathy of Prematurity Plus Disease.Translational vision science & technology · 2019Article
- Estimate of incidence of ROP requiring treatment in extreme preterms and impact on service-7 year review in tertiary unit.Eye (London, England) · 2019Article
Corrections and comments
- Commented on by
Authors and funding
22 authors at 12 institutions in 5 countries.
Funding
Abstract
PurposeTo investigate whether the observed international differences in retinopathy of prematurity (ROP) treatment rates within the Benefits of Oxygen Saturation Targeting (BOOST) II trials might have been caused by international variation in ROP disease grading.MethodsGroups of BOOST II trial ophthalmologists in UK, Australia, and New Zealand (ANZ), and an international reference group (INT) used a web based system to grade a selection of RetCam images of ROP acquired during the BOOST II UK trial. Rates of decisions to treat, plus disease grading, ROP stage grading, ROP zone grading, inter-observer variation within groups and intra-observer variation within groups were measured.ResultsForty-two eye examinations were graded. UK ophthalmologists diagnosed treat-requiring ROP more frequently than ANZ ophthalmologists, 13.9 (3.49) compared to 9.4 (4.46) eye examinations, P=0.038. UK ophthalmologists diagnosed plus disease more frequently than ANZ ophthalmologists, 14.1 (6.23) compared to 8.5 (3.24) eye examinations, P=0.021. ANZ ophthalmologists diagnosed stage 2 ROP more frequently than UK ophthalmologists, 20.2 (5.8) compared to 12.7 (7.1) eye examinations, P=0.026. There were no other significant differences in the grading of ROP stage or zone. Inter-observer variation was higher within the UK group than within the ANZ group. Intra-observer variation was low in both groups.ConclusionsWe have found evidence of international variation in the diagnosis of treatment-requiring ROP. Improved standardisation of the diagnosis of treatment-requiring ROP is required. Measures might include improved training in the grading of ROP, using an international approach, and further development of ROP image analysis software.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.