ArticleThe Plant journal : for cell and molecular biology2017
CYCLING DOF FACTOR 1 represses transcription through the TOPLESS co-repressor to control photoperiodic flowering in Arabidopsis.
Article in The Plant journal : for cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Mineral nutrients as regulators of plant flowering time: A molecular perspective.Journal of integrative plant biology · 2026Review
- Comprehensive analysis of DOF transcription factors and characterization of PlOBP4 during herbaceous peony bud dormancy.Plant cell reports · 2026Article
- Transcriptomic insights into gibberellin-3-mediated regulation of bud dormancy and metabolic transition in pitaya (Hylocereus polyrhizus).Plant cell reports · 2025Article
- A NAC family geneHorticulture research · 2025Article
- Seasonal changes in daily temperature fluctuation control flowering through a time-dependent regulation ofResearch square · 2025Article
- Transcriptional corepressor OsTPR1 regulates tillering and lateral root development in rice.Scientific reports · 2025Article
- Global identification and characterization of soybean TPR genes with expression analysis under photoperiod variations.Scientific reports · 2025Article
- A genome-wide association study reveals that DgFH18 and DgCMO-like are associated with flowering time in orchardgrass (Dactylis glomerata).BMC genomics · 2025Article
- Complex Signaling Networks Underlying Blue-Light-Mediated Floral Transition in Plants.Plants (Basel, Switzerland) · 2025Review
- Structural insights into CDF1 accumulation on the CONSTANS promoter via a plant-specific DNA-binding domain.Nature plants · 2025Article
- AntagonizingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptome Analysis Reveals Sugar and Hormone Signaling Pathways Mediating Flower Induction in Pitaya (International journal of molecular sciences · 2025Article
- Exploring functional InDels and genetic diversity: agro-morphometric and molecular insights into the Western and Eastern gene pools of carrot (Frontiers in plant science · 2025Article
- StCDF1: A 'jack of all trades' clock output with a central role in regulating potato nitrate reduction activity.The New phytologist · 2025Article
- Deciphering Carotenoid and Flowering Pathway Gene Variations in Eastern and Western Carrots (Genes · 2024Article
- Cycling DOF factor mediated seasonal regulation of sexual reproduction and cold response is not conserved inPlant direct · 2024Article
- Exploring CDF gene family in wild potato under salinity stress unveils promising candidates for developing climate-resilient crops.Scientific reports · 2024Article
- The Role ofPlants (Basel, Switzerland) · 2024Article
- CONSTANS, a HUB for all seasons: How photoperiod pervades plant physiology regulatory circuits.The Plant cell · 2024Review
- Evolution and Dynamic Transcriptome of Key Genes of Photoperiodic Flowering Pathway in Water Spinach (International journal of molecular sciences · 2024Article
4 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
CYCLING DOF FACTOR 1 (CDF1) and its homologs play an important role in the floral transition by repressing the expression of floral activator genes such as CONSTANS (CO) and FLOWERING LOCUS T (FT) in Arabidopsis. The day-length-specific removal of CDF1-dependent repression is a critical mechanism in photoperiodic flowering. However, the mechanism by which CDF1 represses CO and FT transcription remained elusive. Here we demonstrate that Arabidopsis CDF proteins contain non-EAR motif-like conserved domains required for interaction with the TOPLESS (TPL) co-repressor protein. This TPL interaction confers a repressive function on CDF1, as mutations of the N-terminal TPL binding domain largely impair the ability of CDF1 protein to repress its targets. TPL proteins are present on specific regions of the CO and FT promoters where CDF1 binds during the morning. In addition, TPL binding increases when CDF1 expression is elevated, suggesting that TPL is recruited to these promoters in a time-dependent fashion by CDFs. Moreover, reduction of TPL activity induced by expressing a dominant negative version of TPL (tpl-1) in phloem companion cells results in early flowering and a decreased sensitivity to photoperiod in a manner similar to a cdf loss-of-function mutant. Our results indicate that the mechanism of CDF1 repression is through the formation of a CDF-TPL transcriptional complex, which reduces the expression levels of CO and FT during the morning for seasonal flowering.
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