ArticleAmerican journal of physical anthropology2017
Malnutrition-related early childhood exposures and enamel defects in the permanent dentition: A longitudinal study from the Bolivian Amazon.
Article in American journal of physical anthropology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 32 citations in OpenAlex.
- Tracing 2500 years of human betaherpesvirus 6A and 6B diversity through ancient DNA.Science advances · 2026Article
- Revisiting Linear Enamel Hypoplasia in Cayo Santiago Rhesus Macaques (Macaca mulatta): How a Stress Marker Relates to Environment and Maternal Lineage in a Rare Rhesus Colony With Known Life History.American journal of primatology · 2025Article
- Difficulty with Dental Caries among Adolescents Who Are Underweight: A Nationwide Study.Journal of pediatrics. Clinical practice · 2024Article
- Nutritional Deficiencies and Associated Oral Health in Adolescents: A Comprehensive Scoping Review.Children (Basel, Switzerland) · 2024Article
- Association between Short Stature at Grade 1 and Permanent Teeth Caries at Grade 6 in Elementary School Children in Japan: A Population-Based Cohort Study.International journal of environmental research and public health · 2024Article
- Molar-Incisor Hypomineralization Is Associated with the Prevalence of Thinness among Schoolchildren in Communities with Different Fluoride Levels in the Drinking Water.International journal of dentistry · 2024Article
- RANTES and developmental defects of enamel in children: A Brazilian prenatal cohort (BRISA).PloS one · 2023Article
- Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review.Frontiers in pediatrics · 2022Article
- Exploring the association of predisposing factors of Cerebral Palsy and developmental defects of enamel: a case-control study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Article
- Malnutrition, enamel defects, and early childhood caries in preschool children in a sub-urban Nigeria population.PloS one · 2020Article
- Early Childhood Caries in Peru.Frontiers in public health · 2019Review
- Dental enamel defects predict adolescent health indicators: A cohort study among the Tsimane' of Bolivia.American journal of human biology : the official journal of the Human Biology Council · 2018Article
- Hypoplasia Resulting from Nutritional Deficiency: A Case Report.International journal of clinical pediatric dentistryArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesWe investigated the relationship between early childhood malnutrition-related measures and subsequent enamel defects in the permanent dentition. MATERIALS AND
methodsThis cohort study included 349 Amerindian adolescents (10-17 years, 52% male) from the Bolivian Amazon. Exposures included: stunted growth (height-for-age z-scores), underweight (weight-for-age z-scores), anemia (hemoglobin), acute inflammation (C-reactive protein) and parasitic infection (hookworm). We measured the occurrence (no/yes) and extent (<1/3, 1/3-2/3, >2/3) of enamel defects. We estimated associations between childhood exposures and enamel defect measures using log-binomial and multinomial logistic regression.
resultsThe prevalence of an enamel defect characterized by an orange peel texture on a large central depression on the labial surface of the central maxillary incisors was 92.3%. During childhood (1-4 years), participants had a high prevalence of stunted growth (75.2%), anemia (56.9%), acute inflammation (39.1%), and hookworm infection (49.6%). We observed associations between childhood height-for-age (OR = 0.65; P = 0.028 for >2/3 extent vs. no EH) and gastrointestinal hookworm infection (OR = 3.43; P = 0.035 for >2/3 extent vs. no defects or <1/3 extent) with enamel defects. DISCUSSION: The study describes a possibly novel form of enamel hypoplasia and provides evidence for associations of malnutrition-related measures in early childhood, including stunted growth and parasitic helminth infection, with the observed enamel defects.
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