ReviewCurrent rheumatology reports2017
Mechanism of New Bone Formation in Axial Spondyloarthritis.
Review in Current rheumatology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Non-steroidal Anti-inflammatory Drugs Are Unlikely to Inhibit Radiographic Progression of Ankylosing Spondylitis: A Systematic Review.Frontiers in medicine · 2019Pooled it
- Certolizumab pegol treatment in axial spondyloarthritis mitigates fat lesion development: 4-year post-hoc MRI results from a phase 3 study.Rheumatology (Oxford, England) · 2022Trial
- Sex differences in axial spondyloarthritis: biological mechanisms, clinical phenotypes, and therapeutic implications - a narrative review.Medicine and pharmacy reports · 2026Review
- In search of a window of opportunity in axial spondyloarthritis: treatment outcomes across different symptom durations.EULAR rheumatology open · 2026Article
- Fibrinogen-to-Platelet Ratio and Hematologic Inflammatory Indexes in Spondylarthritis.Journal of clinical medicine · 2026Article
- Spinal lesions in axial spondyloarthritis: longitudinal assessment of disease-related and degenerative changes.Rheumatology (Oxford, England) · 2026Article
- Inflammation and pain as interconnected targets in axial spondyloarthritis.Nature reviews. Rheumatology · 2026Review
- Clinical and molecular links between chronic systemic inflammation and structural damage in axial spondyloarthritis.Arthritis research & therapy · 2025Article
- Metrnl/Meteorin-like/IL-41, a novel regulator of bone metabolism and disease activity in ankylosing spondylitis: based on multi-omics analysis.Frontiers in immunology · 2025Article
- Axial Imaging in Spondyloarthritis.Rheumatic diseases clinics of North America · 2024Review
- CD_99 G1 neutrophils modulate osteogenic differentiation of mesenchymal stem cells in the pathological process of ankylosing spondylitis.Annals of the rheumatic diseases · 2024Article
- Association of trabecular bone score with disease parameters and vertebral fractures in axial spondyloarthritis.Rheumatology advances in practice · 2024Article
- Impact of bimekizumab and certolizumab pegol on efficacy, safety and osteoblastic activity in radiographic axial spondyloarthritis: results from a phase IIa, multicentre, randomised, double-blind, exploratory study with PET-CT imaging.Therapeutic advances in musculoskeletal disease · 2024Article
- PLCG2 and IFNAR1: The Potential Biomarkers Mediated by Immune Infiltration and Osteoclast Differentiation of Ankylosing Spondylitis in the Peripheral Blood.Mediators of inflammation · 2024Article
- New bone formation at the sacroiliac joint in axial spondyloarthritis: characterization of backfill in MRI and CT.Rheumatology (Oxford, England) · 2023Article
- [Dealing with NSAID in the treatment of axial spondylarthritis].Zeitschrift fur Rheumatologie · 2023Article
- Review
- Osteoimmunology of Spondyloarthritis.International journal of molecular sciences · 2023Review
- Association between changes in serum alkaline phosphatase levels and radiographic progression in ankylosing spondylitis.Scientific reports · 2023Article
- Quantitative prediction of radiographic progression in patients with axial spondyloarthritis using neural network model in a real-world setting.Arthritis research & therapy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of the reviewThe purpose of this review is to discuss new evidence explaining the progress from bony inflammation over repair tissue to new bone formation in axial spondyloartrhitis and its correlations in imaging and histology of the bone. RECENT
findingsData from imaging, histology and treatment interventions indicates that the disease starts with inflammation, followed by replacement of subchondral bone marrow by repair tissue which presence is crucial for the stimulation of new bone formation. The magnetic resonance imaging (MRI) sequences of STIR and T1 are currently the most commonly used imaging techniques to follow this process; explanations are offered for the limited sensitivity to detect these bony changes on MRI in their different phases. Early and effective anti-inflammatory treatment is crucial for the prevention of long-term ankylosis. Whether there are currently also treatment options targeting new bone formation in these patients directly is less clear.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.