Evidence map›Paper›PMID 28752404›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017

Preoperative Neutrophil to Lymphocyte Ratio and Lymphocyte to Monocyte Ratio are Prognostic Factors in Gastric Cancers Undergoing Surgery.

Eva Lieto, Gennaro Galizia, Annamaria Auricchio, Francesca Cardella, Andrea Mabilia, Nicoletta Basile, Giovanni Del Sorbo, Paolo Castellano, Ciro Romano, Michele Orditura and 1 more

Abstract read
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In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  19. Effects of Neoadjuvant Chemotherapy Toxicity and Postoperative Complications on Short-term and Long-term Outcomes After Curative Resection of Gastric Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eva LietoDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy.
Gennaro GaliziaDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy. gennaro.galizia@unicampania.it.ORCID http://orcid.org/0000-0002-6897-0391
Annamaria AuricchioDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy.
Francesca CardellaDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy.
Andrea MabiliaDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy.
Nicoletta BasileDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy.
Giovanni Del SorboDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy.
Paolo CastellanoDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy.
Ciro RomanoDivision of Internal Medicine, Department of Medical and Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, Naples, Italy.
Michele OrdituraDivision of Medical Oncology, F. Magrassi Department of Clinical and Experimental Medicine, Luigi Vanvitelli University of Campania School of Medicine, Naples, Italy.
Vincenzo NapolitanoDivision of GI Tract Surgical Oncology, Department of Surgical Sciences, Luigi Vanvitelli University of Campania School of Medicine, c/o II Policlinico, Edificio 17, Via Pansini, 5, 80131, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer outcome is considered to result from the interplay of several factors, among which host inflammatory and immune status are deemed to play a significant role. The neutrophil-to-lymphocyte ratio (NLR) and the lymphocyte-to-monocyte ratio (LMR) have been profitably used as surrogate markers of host immunoinflammatory status and have also been shown to correlate with outcome in several human tumors. However, only a few studies on these biomarkers have been performed in gastric cancer patients, yielding conflicting results.

methodsData were retrieved from a prospective institutional database. Overall survival (OS) of 401 patients undergoing surgery for gastric cancer between January 2000 and June 2015 as well as disease-free survival (DFS) rates in 297 radically resected patients were calculated. MaxStat analysis was used to select cutoff values for NLR and LMR.

resultsNLR and LMR did not significantly correlate with tumor stage. Patients with a high NLR and a low LMR experienced more tumor recurrences (p < 0.001) and had a higher hazard ratio (HR) for both OS (HR = 2.4 and HR = 2.10; p < 0.001) and DFS (HR = 2.99 and HR = 2.46; p < 0.001) than low NLR and high LMR subjects. Both biomarkers were shown to independently predict OS (HR = 1.65, p = 0.016; HR = 2.01, p = 0.002, respectively) and DFS (HR = 3.04, p = 0.019; HR = 4.76, p = 0.002, respectively). A score system combining both biomarkers was found to significantly correlate with long-term results.

conclusionsA simple prognostic score including preoperative NLR and LMR can be used to easily predict outcome in gastric cancer patients undergoing surgery.

Indexed as

LymphocytesMonocytesNeutrophilsAdenocarcinomaAdultAgedBiomarkersCohort StudiesDisease-Free SurvivalFemaleHumansLeukocyte CountMaleMiddle AgedPrognosisProportional Hazards ModelsBiomarkersGastric cancersInflammatory and immune statusLymphocyte-to-monocyte ratioNeutrophil-to-lymphocyte ratio

Identifiers

PMID28752404

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.