Evidence map›Paper›PMID 28752294›Full record

ArticleJournal of microbiology (Seoul, Korea)2017

Characterization and phylogenetic analysis of Varicella-zoster virus strains isolated from Korean patients.

Min Ho Kim, Jeong Seon Jeon, In Kyo Kim, Ji Seon Park, Hosun Park, Ok Sarah Shin, Chan Hee Lee

Abstract read
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In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  5. Human herpesvirus diversity is altered in HLA class I binding peptides.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Min Ho KimDepartment of Microbiology, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Jeong Seon JeonDepartment of Microbiology, Chungbuk National University, Cheongju, 28644, Republic of Korea.
In Kyo KimDepartment of Microbiology, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Ji Seon ParkDepartment of Microbiology, Chungbuk National University, Cheongju, 28644, Republic of Korea.
Hosun ParkDepartment of Microbiology, College of Medicine, Yeungnam University, Daegu, 42415, Republic of Korea.
Ok Sarah ShinDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, 08308, Republic of Korea.
Chan Hee LeeDepartment of Microbiology, Chungbuk National University, Cheongju, 28644, Republic of Korea. chlee@chungbuk.ac.kr.
Chungbuk National University · KRKorea University · KRYeungnam University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicella-zoster virus (VZV) is a causative agent of chickenpox in primary infection and shingles after its reactivation from latency. Complete or almost-complete genomic DNA sequences for various VZV strains have been reported. Recently, clinical VZV strains were isolated from Korean patients whose genome was sequenced using high-throughput sequencing technology. In this study, we analyzed single nucleotide polymorphism (SNP) of VZV strains to genetically characterize Korean clinical isolates. Phylogenetic analyses revealed that three Korean strains, YC01, YC02, and YC03, were linked to clade 2. Comprehensive SNP analysis identified 86 sites specific for the 5 VZV clades. VZV strains isolated from Korea did not form a phylogenetic cluster. Rather, YC02 and YC03 clustered strongly with Chinese strain 84-7 within clade 2, more specifically cluster 2a. Signature sequences for the cluster 2a were identified and found to play an important role in the separation of cluster 2a strains from other clade 2 strains, as shown in substitution studies. Further genetic analysis with additional strains isolated from Japan, China, and other Asian countries would provide a novel insight into the significance of two distinct subclades within clade 2.

Indexed as

Genetic VariationGenome, ViralHerpesvirus 3, HumanHigh-Throughput Nucleotide SequencingHumansKoreaPhylogenyPolymorphism, Single NucleotideSequence Analysis, DNAClade 2Korean strainsVaricella-zoster virus

Identifiers

PMID28752294
OpenAlexW2738591169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.