Evidence map›Paper›PMID 28752131›Full record

ArticleACS biomaterials science & engineering2016

Multiple Administrations of Viral Nanoparticles Alter

Sourabh Shukla, R Dixon Dorand, Jay T Myers, Sarah E Woods, Neetu M Gulati, Phoebe L Stewart, Ulrich Commandeur, Alex Y Huang, Nicole F Steinmetz

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Systemic Infection ofBioMed research international · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sourabh ShuklaDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
R Dixon DorandDepartment of Pathology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Jay T MyersDepartment of Pediatrics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Sarah E WoodsDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Neetu M GulatiDepartment of Pharmacology, and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Phoebe L StewartDepartment of Pharmacology, and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Ulrich CommandeurInstitute for Molecular Biotechnology, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany.
Alex Y HuangDepartment of Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Nicole F SteinmetzDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Case Western Reserve University · USRWTH Aachen University · DE

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Immunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4M
Mechanistic Dynamic Study of Intranodal Chemokine-aided Antitumor Immune PrimingR01CA154656 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 2011 to 2015
$1.7M
Cdk5 signaling in ICN1-induced T Cell LeukemogenesisR21CA181875 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN, LETTERIO, JOHN JAMES · 2015 to 2016
$379k
Engineering 'Grapevine Virus A' filaments for nanomedical applicationsR03EB020602 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI STEINMETZ, NICOLE FRANZISKA · 2015 to 2016
$159k
Loss of Fractalkine Signaling Affects CNS Tumor Growth via Microglia InteractionsF31CA196265 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI DORAND, RODNEY DIXON · 2015 to 2017
$115k
NCI NIH HHS F31 CA196265NCI NIH HHS R01 CA154656NCI NIH HHS R21 CA181875NIAID NIH HHS T32 AI089474NIBIB NIH HHS R03 EB020602NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Multiple administrations of nanoparticle-based formulations are often a clinical requirement for drug delivery and diagnostic imaging applications. Steady pharmacokinetics of nanoparticles is desirable to achieve efficient therapeutic or diagnostic outcomes over such repeat administrations. While clearance through mononuclear phagocytic system is a key determinant of nanoparticle persistence

Indexed as

antibody responseIgM antibodyintravital imagingnanoparticle circulationrepeat administrationviral nanoparticles

Identifiers

PMID28752131
PMCPMC5526635
OpenAlexW2330981386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.