ArticleNeuroImage. Clinical2017
Sleep onset uncovers thalamic abnormalities in patients with idiopathic generalised epilepsy.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Artifact Reduction in Simultaneous EEG-fMRI: A Systematic Review of Methods and Contemporary Usage.Frontiers in neurology · 2021Pooled it
- Slow wave canonical activity deviation concept: Toward a slow wave-based EEG-fMRI reference map for health-associated network function.iScience · 2026Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Revolutionizing Sleep Science: A Narrative Review of the Historical Origins and Current Applications of Sleep Neuroimaging.Nature and science of sleep · 2025Review
- Commentary: Epileptic seizure clustering and accumulation at transition from activity to rest in GAERS rats.Frontiers in neurology · 2024Article
- The neurophysiologic landscape of the sleep onset: a systematic review.Journal of thoracic disease · 2023Review
- The effects of attention in auditory-visual integration revealed by time-varying networks.Frontiers in neuroscience · 2023Article
- The adjustment mechanism of the spike and wave discharges in thalamic neurons: a simulation analysis.Cognitive neurodynamics · 2022Article
- Article
- Simultaneous EEG-fMRI: What Have We Learned and What Does the Future Hold?Sensors (Basel, Switzerland) · 2022Review
- Altered thalamic connectivity in insomnia disorder during wakefulness and sleep.Human brain mapping · 2021Article
- Editorial: Advances and Applications of the EEG-fMRI Technique on Epilepsies.Frontiers in neurology · 2021Article
- All-night functional magnetic resonance imaging sleep studies.Journal of neuroscience methods · 2019Article
- Spectral entropy indicates electrophysiological and hemodynamic changes in drug-resistant epilepsy - A multimodal MREG study.NeuroImage. Clinical · 2019Article
- Objective and subjective measures of prior sleep-wake behavior predict functional connectivity in the default mode network during NREM sleep.Brain and behavior · 2019Article
- Brain functional connectivity in sleep-related hypermotor epilepsy.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thalamus is crucial for sleep regulation and the pathophysiology of idiopathic generalised epilepsy (IGE), and may serve as the underlying basis for the links between the two. We investigated this using EEG-fMRI and a specific emphasis on the role and functional connectivity (FC) of the thalamus. We defined three types of thalamic FC: thalamocortical, inter-hemispheric thalamic, and intra-hemispheric thalamic. Patients and controls differed in all three measures, and during wakefulness and sleep, indicating disorder-dependent and state-dependent modification of thalamic FC. Inter-hemispheric thalamic FC differed between patients and controls in somatosensory regions during wakefulness, and occipital regions during sleep. Intra-hemispheric thalamic FC was significantly higher in patients than controls following sleep onset, and disorder-dependent alterations to FC were seen in several thalamic regions always involving somatomotor and occipital regions. As interactions between thalamic sub-regions are indirect and mediated by the inhibitory thalamic reticular nucleus (TRN), the results suggest abnormal TRN function in patients with IGE, with a regional distribution which could suggest a link with the thalamocortical networks involved in the generation of alpha rhythms. Intra-thalamic FC could be a more widely applicable marker beyond patients with IGE.
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