Evidence map›Paper›PMID 28752059›Full record

ArticleNeuroImage. Clinical2017

Microstructural abnormalities in white and gray matter in obese adolescents with and without type 2 diabetes.

Arie Nouwen, Alison Chambers, Magdalena Chechlacz, Suzanne Higgs, Jacqueline Blissett, Timothy G Barrett, Harriet A Allen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  19. White Matter Function and Network Abnormalities in Patients with Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  20. Is there a role for higher cognitive processes in the development of obesity in humans?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Arie NouwenSchool of Psychology, University of Birmingham, Birmingham, UK.
Alison ChambersSchool of Psychology, University of Birmingham, Birmingham, UK.
Magdalena ChechlaczSchool of Psychology, University of Birmingham, Birmingham, UK.
Suzanne HiggsSchool of Psychology, University of Birmingham, Birmingham, UK.
Jacqueline BlissettSchool of Psychology, University of Birmingham, Birmingham, UK.
Timothy G BarrettThe Medical School, University of Birmingham, Birmingham, UK.
Harriet A AllenSchool of Psychology, University of Birmingham, Birmingham, UK.
University of Birmingham · GB

Funding

Medical Research Council G0800661Wellcome Trust
6 · The paper itself

Abstract

aims/hypothesesIn adults, type 2 diabetes and obesity have been associated with structural brain changes, even in the absence of dementia. Some evidence suggested similar changes in adolescents with type 2 diabetes but comparisons with a non-obese control group have been lacking. The aim of the current study was to examine differences in microstructure of gray and white matter between adolescents with type 2 diabetes, obese adolescents and healthy weight adolescents.

methodsMagnetic resonance imaging data were collected from 15 adolescents with type 2 diabetes, 21 obese adolescents and 22 healthy weight controls. Volumetric differences in the gray matter between the three groups were examined using voxel based morphology, while tract based spatial statistics was used to examine differences in the microstructure of the white matter.

resultsAdolescents with type 2 diabetes and obese adolescents had reduced gray matter volume in the right hippocampus, left putamen and caudate, bilateral amygdala and left thalamus compared to healthy weight controls. Type 2 diabetes was also associated with significant regional changes in fractional anisotropy within the corpus callosum, fornix, left inferior fronto-occipital fasciculus, left uncinate, left internal and external capsule. Fractional anisotropy reductions within these tracts were explained by increased radial diffusivity, which may suggest demyelination of white matter tracts. Mean diffusivity and axial diffusivity did not differ between the groups. CONCLUSION/

interpretationOur data shows that adolescent obesity alone results in reduced gray matter volume and that adolescent type 2 diabetes is associated with both white and gray matter abnormalities.

Indexed as

Magnetic Resonance ImagingAdolescentAnisotropyBrain MappingDiabetes Mellitus, Type 2Diffusion Magnetic Resonance ImagingFemaleGray MatterHumansImage Processing, Computer-AssistedMaleNerve Fibers, MyelinatedNeural PathwaysObesityWhite MatterDemyelinationGray matterHbA1c, Haemoglobin A1cObesityType 2 diabetesWhite matter

Identifiers

PMID28752059
PMCPMC5514690
OpenAlexW2730926469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.