ArticleMolecular metabolism2017
Maternal obesity programs increased leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner.
Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss.iScience · 2026Article
- The Injection of Lipids Into Yolk Sac has Been Shown to Alter the Lipid Metabolism of Adult Nile Tilapia (Aquaculture nutrition · 2026Article
- Obesity and Its Role in Fetal Programming-A Narrative Review.Nutrients · 2025Review
- Impact ofAdvanced pharmaceutical bulletin · 2025Article
- Sex-specific role of epigenetic modification of a leptin upstream enhancer in adipose tissue.Clinical epigenetics · 2025Article
- DNA methylation and demethylation in adipocyte biology: roles of DNMT and TET proteins in metabolic disorders.Frontiers in endocrinology · 2025Review
- Review
- Transcriptional and epigenetic changes after dietary and surgical weight loss interventions in an animal model of obesity.International journal of obesity (2005) · 2024Article
- The Impact of Maternal Obesity on Adipose Progenitor Cells.Biomedicines · 2023Review
- Programming of metabolism by adipokines during development.Nature reviews. Endocrinology · 2023Review
- Dietary trends and the decline in male reproductive health.Hormones (Athens, Greece) · 2023Review
- Parental obesity-induced changes in developmental programming.Frontiers in cell and developmental biology · 2022Review
- Developmental programming of offspring adipose tissue biology and obesity risk.International journal of obesity (2005) · 2021Review
- Article
- Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view.World journal of diabetes · 2021Review
- Article
- Microbiome-immune-metabolic axis in the epidemic of childhood obesity: Evidence and opportunities.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring.International journal of obesity (2005) · 2019Article
- Epigenetic Programming of Adipose Tissue in the Progeny of Obese Dams.Current genomics · 2019Review
- Maternal Obesity, Maternal Overnutrition and Fetal Programming: Effects of Epigenetic Mechanisms on the Development of Metabolic Disorders.Current genomics · 2019Review
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAccording to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and accelerated growth in neonates predispose offspring to white adipose tissue (WAT) accumulation. In rodents, adipogenesis mainly develops during lactation. The mechanisms underlying the phenomenon known as developmental programming remain elusive. We previously reported that adult rat offspring from high-fat diet-fed dams (called HF) exhibited hypertrophic adipocyte, hyperleptinemia and increased leptin mRNA levels in a depot-specific manner. We hypothesized that leptin upregulation occurs via epigenetic malprogramming, which takes place early during development of WAT.
methodsAs a first step, we identified
resultsPND12 is an active period for epigenomic remodeling in both deposits especially in the upstream enhancer, consistent with leptin gene induction during adipogenesis. Unlike iWAT, some of these epigenetic marks were still observable in pWAT of weaned HF offspring. Retained marks were only visible in pWAT of 9-month-old HF rats that showed a persistent "expandable" phenotype.
conclusionsConsistent with the DOHaD hypothesis, persistent epigenetic remodeling occurs at regulatory regions especially within intergenic sequences, linked to higher leptin gene expression in adult HF offspring in a depot-specific manner.
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