ArticleMolecular metabolism2017
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming.
Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 61 citations in OpenAlex.
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- Characterization of subcutaneous and visceral de-differentiated fat cells.Molecular metabolism · 2025Article
- Genomic insights into the contribution of de novo lipogenesis to intramuscular fat deposition in chicken.Journal of advanced research · 2024Article
- Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARActa pharmaceutica Sinica. B · 2023Article
- A subpopulation of lipogenic brown adipocytes drives thermogenic memory.Nature metabolism · 2023Article
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- Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes.Nature communications · 2023Article
- Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide.Journal of visualized experiments : JoVE · 2023Article
- Physiological and pathological roles of lipogenesis.Nature metabolism · 2023Review
- De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics.Nature communications · 2023Article
- Adipose tissue at single-cell resolution.Cell metabolism · 2023Review
- Epicardial adipocytes in the pathogenesis of atrial fibrillation: An update on basic and translational studies.Frontiers in endocrinology · 2023Review
- Interactions between central nervous system and peripheral metabolic organs.Science China. Life sciences · 2022Review
- Strength training alters the tissue fatty acids profile and slightly improves the thermogenic pathway in the adipose tissue of obese mice.Scientific reports · 2022Article
- Review
- Eosinophils regulate intra-adipose axonal plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reciprocal signaling between adipose tissue depots and the central nervous system.Frontiers in cell and developmental biology · 2022Review
- A novel c.-652C>T mutation in UCHL1 gene is associated with the growth performance in Yangzhou goose.Poultry science · 2021Article
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12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in the regulation of systemic glucose homeostasis are not fully understood. METHODS &
resultsHere we show adipocyte DNL controls crosstalk to localized sympathetic neurons that mediate expansion of beige/brite adipocytes within inguinal white adipose tissue (iWAT). Induced deletion of FASN in white and brown adipocytes of mature mice (iAdFASNKO mice) enhanced glucose tolerance, UCP1 expression, and cAMP signaling in iWAT. Consistent with induction of adipose sympathetic nerve activity, iAdFASNKO mice displayed markedly increased neuronal tyrosine hydroxylase (TH) and neuropeptide Y (NPY) content in iWAT. In contrast, brown adipose tissue (BAT) of iAdFASNKO mice showed no increase in TH or NPY, nor did FASN deletion selectively in brown adipocytes (UCP1-FASNKO mice) cause these effects in iWAT.
conclusionsThese results demonstrate that downregulation of fatty acid synthesis via FASN depletion in white adipocytes of mature mice can stimulate neuronal signaling to control thermogenic programming in iWAT.
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