ArticleTurkish journal of anaesthesiology and reanimation2017
Short-Term and Long-Term Effects of Dexamethasone on Cognitive Dysfunction Induced by Sevoflurane in Adult Rats.
Article in Turkish journal of anaesthesiology and reanimation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Exposure to halogenated ethers causes neurodegeneration and behavioural changes in young healthy experimental animals: a systematic review and meta analyses.Scientific reports · 2023Pooled it
- Recent advances and perspectives of postoperative neurological disorders in the elderly surgical patients.CNS neuroscience & therapeutics · 2022Review
- Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway.Experimental and therapeutic medicine · 2021Article
- MicroRNA-1297 suppressed the Akt/GSK3The Journal of international medical research · 2021Article
- Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone.Frontiers in pharmacology · 2021Article
- Research Progress on the Role of Inflammatory Mechanisms in the Development of Postoperative Cognitive Dysfunction.BioMed research international · 2021Review
- Cistanches alleviates sevoflurane-induced cognitive dysfunction by regulating PPAR-γ-dependent antioxidant and anti-inflammatory in rats.Journal of cellular and molecular medicine · 2020Article
- Effects of Memantine in a Mouse Model of Postoperative Cognitive Dysfunction.Behavioral sciences (Basel, Switzerland) · 2019Article
- The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment.Frontiers in psychiatry · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePostoperative cognitive dysfunction (POCD) is common after anaesthesia in elderly patients. However, it may appear in patients of all ages. The main pathogenesis of cognitive dysfunction remains unclear, although there is some evidence that brain inflammation may alter cognitive abilities. In the present study, we aim to evaluate short-term and long-term effects of dexamethasone on cognitive dysfunction induced by sevoflurane anaesthesia in adult rats.
methodsSeven-month-old 30 male Wistar albino rats were randomised into three groups: sevoflurane group (exposure to sevoflurane), sevoflurane + dexamethasone group (exposure to sevoflurane and dexamethasone injection), and control group (exposure to 100% oxygen). Spatial learning and short-term (7 days after exposure) and long-term (30 days after exposure) memory were evaluated using Morris water maze test.
resultsSevoflurane induced significant deficit in spatial learning and short-term and long-term memory in adult rats. Dexamethasone-treated animals exposed to sevoflurane had equivalent performance as control animals in training and probe trials.
conclusionSevoflurane may impair spatial learning and short-term and long-term memories in adult rats. The co-administration of dexamethasone and sevoflurane may ameliorate short-term and long-term cognitive dysfunctions induced by sevoflurane in adult rats.
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