ReviewTurkish journal of anaesthesiology and reanimation2017
Changing Definitions of Sepsis.
Review in Turkish journal of anaesthesiology and reanimation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Healthcare costs after sepsis: a systematic review.Critical care (London, England) · 2025Pooled it
- Application of norepinephrine in the treatment of septic shock: a meta-analysis.Irish journal of medical science · 2025Pooled it
- Norepinephrine in Septic Shock: A Systematic Review and Meta-analysis.The western journal of emergency medicine · 2021Pooled it
- Microbe on the move:Journal of bacteriology · 2026Review
- Early ΔNLR Outperforms Baseline Inflammatory Markers in Predicting Short-Term Outcomes in Sepsis.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic and prognostic utility of neutrophil CD64 and monocyte HLA-DR in adult sepsis patients.BMC research notes · 2026Observational
- Telodendrimer nanotrap for selective cytokine removal from sepsis patient plasma.Frontiers in immunology · 2026Article
- The Study of Novel Sepsis Biomarkers Presepsin, Interleukin-27, Hepcidin, Plasma Chitotriosidase in Intensive Care Unit Patients with Sepsis and Correlation with Serum Procalcitonin Levels.Annals of African medicine · 2026Article
- Assessment of Vascular Endothelial Dysfunction in Septic Patients Using Brachial Flow-Mediated Dilation: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Prognostic value of low-cost white blood cell indices and procalcitonin for mortality in Rwandan sepsis patients: a prospective intensive care unit study.Tropical medicine and health · 2025Article
- NETosis and pyroptosis of immune cells in sepsis.Journal of translational internal medicine · 2025Article
- Bacteriological profile and antimicrobial resistance in sepsis cases in intensive care units in Lubumbashi: challenges and perspectives.Annals of clinical microbiology and antimicrobials · 2025Article
- Performance of Early Sepsis Screening Tools for Timely Diagnosis and Antibiotic Stewardship in a Resource-Limited Thai Community Hospital.Antibiotics (Basel, Switzerland) · 2025Article
- Maternal sepsis due to Bacteroides fragilis: a case report and review of the literature.Journal of medical case reports · 2025Review
- A novel scoring system for evaluating mortality risk of patients with sepsis during early hospitalization.BMC infectious diseases · 2025Article
- Influence of Surgical Procedures on C-Reactive Protein Levels in Severely Burned Patients: Preliminary Analysis on Implications for Early Sepsis Diagnosis.International journal of molecular sciences · 2025Article
- Predicting ICU Mortality Among Septic Patients Using Machine Learning Technique.Journal of clinical medicine · 2025Article
- Micromeria congesta Alleviates LPS-Induced Inflammation, Apoptosis, Oxidative Stress and DNA Damage in Rat Heart and Kidneys.Veterinary medicine and science · 2025Article
- Population-specific genetic-risk scores enable improved prediction of mortality within 28 days of sepsis onset: a retrospective Taiwanese cohort study.Journal of intensive care · 2025Article
- Blood RNA biomarkers and a point-of-care elastase assay for detecting host immune activation in suspected sepsis: Trajectory matters.PloS one · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is one of the main causes of morbidity and mortality in critically ill patients despite the use of modern antibiotics and resuscitation therapies. Outcomes in sepsis have improved overall, probably because of an enhanced focus on early diagnosis and other improvements in supportive care, but mortality rates still remain unacceptably high. The diagnosis and definition of sepsis is a critical problem due to the heterogeneity of this disease process. Although it is apparent that much more needs to be done to advance our understanding, sepsis and related terms remain difficult to define. A 1991 consensus conference developed initial definitions that systemic inflammatory response syndrome (SIRS) to infection would be called sepsis. Definitions of sepsis and septic shock were revised in 2001 to incorporate the threshold values for organ damage. In early 2016, the new definitions of sepsis and septic shock have changed dramatically. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The consensus document describes organ dysfunction as an acute increase in total Sequential Organ Failure Assessment (SOFA) score two points consequently to the infection. A significant change in the new definitions is the elimination of any mention of SIRS. The Sepsis-3 Task Force also introduced a new bedside index, called the qSOFA, to identify outside of critical care units patients with suspected infection who are likely to develop sepsis. Recently updated the consensus definitions improved specificity compared with the previous descriptions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.