ReviewJournal of ophthalmology2017
Clinical Features and Treatments of Syphilitic Uveitis: A Systematic Review and Meta-Analysis.
Review in Journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026Review
- Case 23: A 26-Year-Old Man Presenting With Right-Eye Visual Disturbances.Journal of Korean medical science · 2026Article
- The use of non-mydriatic ocular fundus imaging in the emergency department for detection of ocular syphilis presenting as presumed "papilledema": a case series.Frontiers in neurology · 2026Article
- Clinical outcomes of ocular syphilis within the Great Plains region: potential syndemic impact of methamphetamine use.Eye (London, England) · 2025Observational
- Syphilitic Uveitis: Clinical Features, Treatment, and Outcome.The American journal of case reports · 2025Article
- Clinical manifestations and treatment prognosis of patients with co-infection of ocular syphilis and HIV.BMC ophthalmology · 2025Article
- Rapidly Progressive Bilateral Syphilitic Optic Neuritis in an Elderly Patient: A Case Report.Cureus · 2025Article
- Article
- Ocular vs neurosyphilis. are they the same? A guide to investigation and management.Eye (London, England) · 2024Review
- Diagnosis and treatment of syphilitic uveitis: Taiwan experts consensus.Journal of the Chinese Medical Association : JCMA · 2024Article
- Article
- Acute vision changes as the presenting symptom of ocular syphilis - A case series of two.IDCases · 2024Article
- Assessment of Visual Acuity Outcomes in Ocular Syphilis Treated With Adjunctive Topical or Oral Steroids.Cureus · 2023Article
- Clinical Features of Syphilis Patients with Ocular Symptoms as the Initial Manifestation.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Clinical features and incidence of visual improvement following systemic antibiotic treatment in patients with syphilitic uveitis.Scientific reports · 2022Article
- Ocular Syphilis: A Case Report.Cureus · 2022Article
- CXCL13, CXCL10 and CXCL8 as Indicators of Ocular and Neurological Involvement in Patients With Ocular Syphilis: An Observational Descriptive Study.Frontiers in ophthalmology · 2022Article
- Ocular syphilis resurgence in an urban underserved community in the United States.International journal of ophthalmology · 2022Article
- Spirochetal uveitis: Spectrum of clinical manifestations, diagnostic and therapeutic approach, final outcome and epidemiological data.International ophthalmology · 2021Article
- Monocular syphilitic uveitis.BMJ case reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the clinical features and efficacies of treatments for syphilitic uveitis.
methodsPubMed was searched for studies of syphilitic uveitis published between January 1990 and October 2016. The clinical features were summarized and appraised. The pooled success rate was defined as an improved or maintained final visual acuity and was calculated with 95% confidence intervals (CIs). Heterogeneity, subgroup analysis, sensitivity analysis, and publication bias were assessed.
resultsThirty-two studies involving 670 patients were analyzed. The most common type of syphilitic uveitis was papillitis. The pooled success rate was 0.91 (95% CI 0.84-0.97) for antibacterial agents alone (15 studies, 286 patients); 0.95 (95% CI 0.91-0.98) for antibacterial agents and systemic corticosteroids combined (11 studies, 245 patients); and 0.91 (95% CI 0.80-0.98) for antibacterial agents, systemic corticosteroids, and other immunosuppressants combined (3 studies, 73 patients). Subgroup analyses revealed no correlations of the efficacy of antibacterial agent monotherapy with study characteristics, such as human immunodeficiency virus coinfection status.
conclusionsThis systematic review and meta-analysis revealed the efficacy of antibacterial agents for treating syphilitic uveitis. Coadministration of systemic corticosteroids or immunosuppressants did not elicit further improvements in the clinical outcomes of antibacterial agents.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.