Evidence map›Paper›PMID 28751821›Full record

ArticleMediators of inflammation2017

Immunomodulation of RA Patients' PBMC with a Multiepitope Peptide Derived from Citrullinated Autoantigens.

Smadar Gertel, Gidi Karmon, Sivan Vainer, Ora Shovman, Martin Cornillet, Guy Serre, Yehuda Shoenfeld, Howard Amital

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Peptide-Based Vaccination Therapy for Rheumatic Diseases.Journal of immunology research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Smadar GertelZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 5262100 Ramat-Gan, Israel.ORCID 0000-0001-7949-7184
Gidi KarmonZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 5262100 Ramat-Gan, Israel.
Sivan VainerZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 5262100 Ramat-Gan, Israel.
Ora ShovmanZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 5262100 Ramat-Gan, Israel.
Martin CornilletUnité Différenciation Epithéliale et Autoimmunité Rhumatoïde, Université de Toulouse-INSERM, Toulouse, France.
Guy SerreUnité Différenciation Epithéliale et Autoimmunité Rhumatoïde, Université de Toulouse-INSERM, Toulouse, France.
Yehuda ShoenfeldZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 5262100 Ramat-Gan, Israel.
Howard AmitalZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 5262100 Ramat-Gan, Israel.ORCID 0000-0002-5406-7716
Tel Aviv University · ILInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Citrullinated peptides are used for measuring anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA). Accumulation of citrullinated proteins in the inflamed synovium suggests that they may be good targets for inducing peripheral tolerance. In view of the multiplicity of citrullinated autoantigens described as ACPA targets, we generated a multiepitope citrullinated peptide (Cit-ME) from the sequences of major citrullinated autoantigens: filaggrin,

Indexed as

AdultAgedArthritis, RheumatoidAutoantibodiesAutoantigensCitrullinationCollagen Type IIEpitopesFemaleFibrinogenFilaggrin ProteinsHumansImmunomodulationLeukocytes, MononuclearMaleMiddle AgedAutoantibodiesAutoantigensCollagen Type IIEpitopesFGB protein, humanFibrinogenFilaggrin ProteinsFLG protein, humanVimentin

Identifiers

PMID28751821
PMCPMC5497640
OpenAlexW2701735156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.