ArticleInternational journal of obesity (2005)2018
Modifiable risk factors in the first 1000 days for subsequent risk of childhood overweight in an Asian cohort: significance of parental overweight status.
Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04601779 (INFANT HEALTH- Supporting Infants' Mental Health and Healthy Weight Development Through Community Health Nurses' Promoting Sensitive Parenting), which is not on this map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INFANT HEALTH- Supporting Infants' Mental Health and Healthy Weight Development Through Community Health Nurses' Promoting Sensitive Parenting
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Effect of Elective Cesarean Section on Children's Obesity From Birth to Adolescence: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Change in modifiable maternal characteristics and behaviours between consecutive pregnancies and offspring adiposity: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- The association between maternal body mass index and child obesity: A systematic review and meta-analysis.PLoS medicine · 2019Pooled it
- Nutrition in early life, epigenetics and lifelong health - evidence from cohort and intervention studies.The Proceedings of the Nutrition Society · 2025Review
- The Association Between the Early Introduction of Solid Food and Childhood Obesity Risk: A Systematic Review.Cureus · 2025Review
- Longitudinal association of cumulative risk factors in early life, genetic risk, and healthy lifestyles during adulthood with the risk of type 2 diabetes.BMC medicine · 2025Article
- Article
- The Accumulative Effect of Multiple Postnatal Risk Factors with the Risk of Being Overweight/Obese in Late Childhood.Nutrients · 2024Article
- Article
- Infant Obesity Prevention Programs for Underrepresented Mothers in a Home Visiting Program: A Qualitative and Community-Engaged Needs Assessment.Community health equity research & policy · 2024Article
- Caregiver Influences on Eating Behaviors in Children: An Opportunity for Preventing Obesity.Current atherosclerosis reports · 2023Review
- How do local authority plans to tackle obesity reflect systems thinking?Perspectives in public health · 2023Article
- Parent-Offspring Associations in Body Composition: Findings From the Southampton Women's Survey Prospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2023Article
- Peri-Conceptional Folic Acid Supplementation and Children's Physical Development: A Birth Cohort Study.Nutrients · 2023Article
- The impact of obesity: a narrative review.Singapore medical journal · 2023Review
- Article
- Predicting childhood overweight status by accelerated weight gain from neonatal period to infancy.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Developing a community facilitator-led participatory learning and action women's group intervention to improve infant feeding, care and dental hygiene practices in South Asian infants: NEON programme.Health expectations : an international journal of public participation in health care and health policy · 2022Article
- A Golden Thread approach to transforming Maternal and Child Health in Singapore.BMC pregnancy and childbirth · 2022Article
- Diet Modification before or during Pregnancy on Maternal and Foetal Outcomes in Rodent Models of Maternal Obesity.Nutrients · 2022Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
BACKGROUND/
objectiveMany studies have identified early-life risk factors for subsequent childhood overweight/obesity, but few have evaluated how they combine to influence risk of childhood overweight/obesity. We examined associations, individually and in combination, of potentially modifiable risk factors in the first 1000 days after conception with childhood adiposity and risk of overweight/obesity in an Asian cohort.
methodsSix risk factors were examined: maternal pre-pregnancy overweight/obesity (body mass index (BMI) ⩾25 kg m
resultsOf 858 children followed up at 48 months, 172 (19%) had none, 274 (32%) had 1, 244 (29%) had 2, 126 (15%) had 3 and 42 (5%) had ⩾4 risk factors. Adjusting for confounders, significant graded positive associations were observed between number of risk factors and adiposity outcomes at 48 months. Compared with children with no risk factors, those with four or more risk factors had s.d. unit increases of 0.78 (95% confidence interval 0.41-1.15) for BMI, 0.79 (0.41-1.16) for WHtR, 0.46 (0.06-0.83) for SSF and 0.67 (0.07-1.27) for FMI. The adjusted relative risk of overweight/obesity in children with four or more risk factors was 11.1(2.5-49.1) compared with children with no risk factors. Children exposed to maternal pre-pregnancy (11.8(9.8-13.8)%) or paternal overweight status (10.6(9.6-11.6)%) had the largest individual predicted probability of child overweight/obesity.
conclusionsEarly-life risk factors added cumulatively to increase childhood adiposity and risk of overweight/obesity. Early-life and preconception intervention programmes may be more effective in preventing overweight/obesity if they concurrently address these multiple modifiable risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.