ArticleScientific reports2017
Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Extracellular Vesicles in Cardiac Amyloidosis: From Pathogenesis to Clinical Applications.Diagnostics (Basel, Switzerland) · 2026Review
- Placental syncytial knots in the spectrum of maternal vascular malperfusion: mechanisms and clinical implications.Vascular biology (Bristol, England) · 2026Article
- Integrative structural profiling and ligand optimisation across the transthyretin mutational landscape.NPJ systems biology and applications · 2025Article
- History of hypertensive disorders of pregnancy and risk of Alzheimer's disease and vascular dementia.Frontiers in neuroendocrinology · 2025Review
- Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia.Biomedicines · 2024Review
- Autophagy in reproduction and pregnancy-associated diseases.iScience · 2024Review
- Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia.Cellular and molecular life sciences : CMLS · 2024Article
- Protein Misfolding in Pregnancy: Current Insights, Potential Mechanisms, and Implications for the Pathogenesis of Preeclampsia.Molecules (Basel, Switzerland) · 2024Review
- Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia.Nature communications · 2023Article
- Article
- Blood Plasma Calorimetric Profiles of Women with Preeclampsia: Effect of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Preeclampsia and syncytiotrophoblast membrane extracellular vesicles (STB-EVs).Clinical science (London, England : 1979) · 2022Review
- Evidence From Human Placenta, Endoplasmic Reticulum-Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Hypoxia-Reoxygenation Impairs Autophagy-Lysosomal Machinery in Primary Human Trophoblasts Mimicking Placental Pathology of Early-Onset Preeclampsia.International journal of molecular sciences · 2022Article
- New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review).Experimental and therapeutic medicine · 2022Review
- Extracellular Vesicles Contribute to the Metabolism of Transthyretin Amyloid in Hereditary Transthyretin Amyloidosis.Frontiers in molecular biosciences · 2022Article
- Assembly of Cytoplasmic Stress Granules in Placentas in Women with Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease.Scientific reports · 2021Article
- Article
- Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.