ArticleScientific reports2017
CT-perfusion stroke imaging: a threshold free probabilistic approach to predict infarct volume compared to traditional ischemic thresholds.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effect of endovascular therapy in large anterior circulation ischaemic strokes: A systematic review and meta-analysis of randomised controlled trials.European stroke journal · 2023Pooled it
- Standardizing the estimation of ischemic regions can harmonize CT perfusion stroke imaging.European radiology · 2024Article
- Assessment of Irreversible Tissue Injury in Extensive Ischemic Stroke-Potential of Quantitative Cerebral Perfusion.Translational stroke research · 2023Article
- Preliminary experience of CT imaging of the ischaemic brain penumbra through spectral processing of multiphasic CTA datasets.Scientific reports · 2023Article
- Low baseline ischemic water uptake is directly related to overestimation of CT perfusion-derived ischemic core volume.Scientific reports · 2022Article
- Probability maps classify ischemic stroke regions more accurately than CT perfusion summary maps.European radiology · 2022Article
- Prediction of midline shift after media ischemia using computed tomography perfusion.BMC medical imaging · 2022Article
- Clinical Imaging of the Penumbra in Ischemic Stroke: From the Concept to the Era of Mechanical Thrombectomy.Frontiers in cardiovascular medicine · 2022Review
- Artificial intelligence for localization of the acute ischemic stroke by non-contrast computed tomography.PloS one · 2022Article
- Predicting the tissue outcome of acute ischemic stroke from acute 4D computed tomography perfusion imaging using temporal features and deep learning.Frontiers in neuroscience · 2022Article
- A Review on Computer Aided Diagnosis of Acute Brain Stroke.Sensors (Basel, Switzerland) · 2021Review
- Ensemble learning accurately predicts the potential benefits of thrombolytic therapy in acute ischemic stroke.Quantitative imaging in medicine and surgery · 2021Article
- [Imaging-based patient selection for mechanical thrombectomy based on time since symptom onset].Der Nervenarzt · 2021Review
- Predictive Value of CT Brain Perfusion Studies in Acute Ischemic Infarct Taking MRI Stroke Protocol As Gold Standard.Cureus · 2021Article
- Evaluation and Prediction of Post-stroke Cerebral Edema Based on Neuroimaging.Frontiers in neurology · 2021Review
- The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed.Frontiers in neurology · 2021Article
- Ischemic lesion growth in acute stroke: Water uptake quantification distinguishes between edema and tissue infarct.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Localized prediction of tissue outcome in acute ischemic stroke patients using diffusion- and perfusion-weighted MRI datasets.PloS one · 2020Article
- Clinical application value of brain CT perfusion imaging in the treatment of acute ischemic stroke thrombolytic therapy.Experimental and therapeutic medicine · 2019Article
- [Imaging in acute ischemic stroke using automated postprocessing algorithms].Der Nervenarzt · 2018Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim was to evaluate a novel method of threshold-free prediction of brain infarct from computed tomography perfusion (CTP) imaging in comparison to conventional ischemic thresholds. In a multicenter cohort of 161 patients with acute large vessel occlusion who received endovascular therapy, brain infarction was predicted by CTP using (1) optimized parameter cut-off values determined by ROC curve analysis and (2) probabilistic logistic regression threshold-free analysis. Predicted infarct volumes and prediction errors based on four perfusion parameter maps were compared against observed infarcts. In 93 patients with successful recanalization, the mean observed infarct volume was 35.7 ± 61.9 ml (the reference for core infarct not savable by reperfusion). Optimal parameter thresholds predicted mean infarct volumes between 53.2 ± 44.4 and 125.0 ± 95.4 ml whereas threshold-free analysis predicted mean volumes between 35.9 ± 28.5 and 36.1 ± 29.0 ml. In 68 patients with persistent occlusion, the mean observed infarct volume was 113.4 ± 138.3 ml (the reference to define penumbral infarct savable by reperfusion). Predicted mean infarct volumes by parameter thresholds ranged from 91.4 ± 81.5 to 163.8 ± 135.7 ml, by threshold-free analysis from 113.2 ± 89.9 to 113.5 ± 89.0 ml. Threshold-free prediction of infarct volumes had a higher precision and lower patient-specific prediction error than conventional thresholding. Penumbra to core lesion mismatch estimate may therefore benefit from threshold-free CTP analysis.
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