ArticleScientific reports2017
Morpho-functional characterization of the systemic venous pole of the reptile heart.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Localization and electrophysiological characterization of the dominant pacemaker in the adult chicken sinoatrial junction.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- The simple morphology of the sunfish heart.Journal of anatomy · 2025Article
- Electrophysiological evidence for the right atrioventricular pacemaker ring in the reptile heart.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Anatomy of the heart of the leatherback turtle.Journal of anatomy · 2022Article
- Anatomy of the heart with the highest heart rate.Journal of anatomy · 2022Article
- Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!The Journal of general physiology · 2022Article
- Reptiles as a Model System to Study Heart Development.Cold Spring Harbor perspectives in biology · 2020Review
- Smooth Muscle in Cardiac Chambers is Common in Turtles and Extensive in the Emydid Turtle, Trachemys scripta.Anatomical record (Hoboken, N.J. : 2007) · 2020Article
- Low incidence of atrial septal defects in nonmammalian vertebrates.Evolution & development · 2020Article
- A characterization of the electrophysiological properties of the cardiomyocytes from ventricle, atrium and sinus venosus of the snake heart.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Sinus venosus incorporation: contentious issues and operational criteria for developmental and evolutionary studies.Journal of anatomy · 2019Review
- Comparative analysis of avian hearts provides little evidence for variation among species with acquired endothermy.Journal of morphology · 2019Article
- Evolution and Development of the Atrial Septum.Anatomical record (Hoboken, N.J. : 2007) · 2019Review
- Examples of Weak, If Not Absent, Form-Function Relations in the Vertebrate Heart.Journal of cardiovascular development and disease · 2018Review
- The beat goes on.eLife · 2018Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammals evolved from reptile-like ancestors, and while the mammalian heart is driven by a distinct sinus node, a sinus node is not apparent in reptiles. We characterized the myocardial systemic venous pole, the sinus venosus, in reptiles to identify the dominant pacemaker and to assess whether the sinus venosus remodels and adopts an atrium-like phenotype as observed in mammals. Anolis lizards had an extensive sinus venosus of myocardium expressing Tbx18. A small sub-population of cells encircling the sinuatrial junction expressed Isl1, Bmp2, Tbx3, and Hcn4, homologues of genes marking the mammalian sinus node. Electrical mapping showed that hearts of Anolis lizards and Python snakes were driven from the sinuatrial junction. The electrical impulse was delayed between the sinus venosus and the right atrium, allowing the sinus venosus to contract and aid right atrial filling. In proximity of the systemic veins, the Anolis sinus venosus expressed markers of the atrial phenotype Nkx2-5 and Gja5. In conclusion, the reptile heart is driven by a pacemaker region with an expression signature similar to that of the immature sinus node of mammals. Unlike mammals, reptiles maintain a sinuatrial delay of the impulse, allowing the partly atrialized sinus venosus to function as a chamber.
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