ArticleScience (New York, N.Y.)2017
Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.
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In one paragraph
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
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Who cites it
68 citing papers in PubMed, 118 citations in OpenAlex.
- Self-modulation of motor cortex activity after stroke: a randomized controlled trial.Brain : a journal of neurology · 2022Trial
- Article
- Motor Recovery After a Hemispherectomy: Review of Mechanisms and the Potential of Neuromodulation to Enhance Motor Outcomes.Journal of child neurology · 2026Review
- Motor Impairment and Adaptation in a Novel Nonhuman Primate Model of Internal Capsule Infarct.Stroke · 2026Article
- The Impact of Developmental and Genetic Influences on Neural Circuits.Brain, behavior and evolution · 2026Review
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Evolutionary expansion of the corticospinal system is linked to dexterity inbioRxiv : the preprint server for biology · 2025Article
- Article
- Proprioceptive synaptic dysfunction is a key feature in mice and humans with spinal muscular atrophy.Brain : a journal of neurology · 2025Article
- Corticospinal Tract Development, Evolution, and Skilled Movements.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- Organization and development of bilateral somatosensory feedback projections in mice.iScience · 2025Article
- Amyotrophic lateral sclerosis represents corticomotoneuronal system failure.Muscle & nerve · 2025Review
- The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents.Frontiers in neural circuits · 2025Review
- A multi-omic single-cell landscape of cellular diversification in the developing human cerebral cortex.Computational and structural biotechnology journal · 2024Article
- Human-specific genetic modifiers of cortical architecture and function.Current opinion in genetics & development · 2024Review
- Article
- Review
- Anatomical and functional analysis of the corticospinal tract in an FRDA mouse model.bioRxiv : the preprint server for biology · 2024Article
- Review
- Phylogenetic reduction of the magnocellular red nucleus in primates and inter-subject variability in humans.Frontiers in neuroanatomy · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 3 countries.
Zirong GuDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.ORCID 0000-0002-8262-7573
John KalambogiasDepartment of Cellular, Molecular, and Biomedical Sciences, City University of New York School of Medicine, New York, NY 10031, USA.ORCID 0000-0002-4854-7449
Shin YoshiokaDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Wenqi HanDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-0093-4474
Zhuo LiDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-3692-8989
Yuka Imamura KawasawaDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-8638-6738
Sirisha PochareddyDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-9505-8090
Zhen LiDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Fuchen LiuDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-0380-850X
Xuming XuDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0001-5424-6709
H. R. Sagara WijeratneDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Masaki UenoDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Emily BlatzDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.ORCID 0000-0001-7309-6451
Joseph SalomoneDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.ORCID 0000-0002-5972-3452
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, 565-0871, Japan.
Mladen-Roko RasinDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-3063-6096
Brian GebeleinDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.ORCID 0000-0001-9791-9061
Matthew T WeirauchCenter for Autoimmune Genomics and Etiology, Division of Biomedical Informatics, and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0001-7977-9122
Nenad SestanDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-0966-9619
John H MartinDepartment of Cellular, Molecular, and Biomedical Sciences, City University of New York School of Medicine, New York, NY 10031, USA. yutaka.yoshida@cchmc.org jmartin@ccny.cuny.edu.ORCID 0000-0002-8670-8469
Yutaka YoshidaDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA. yutaka.yoshida@cchmc.org jmartin@ccny.cuny.edu.ORCID 0000-0003-0664-0888
Cincinnati Children's Hospital Medical Center · USYale University · USRutgers, The State University of New Jersey · USThe Graduate Center, CUNY · USThe University of Osaka · JP
Funding
Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ZHIGANG HE · 1998 to 2026
$21.3M Functional Genomics of Human Brain DevelopmentP50MH106934 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2014 to 2019
$7.9MTranscriptional and Epigenetic Signatures of Human Brain Development and AutismU01MH103339 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD, STATE, MATTHEW W. · 2014 to 2017
$6.5MSynapse elimination in the central nervous systemR01NS093002 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI YOSHIDA, YUTAKA · 2015 to 2024
$4.6MMechanisms of Homeodomain Transcriptional SpecificityR01GM079428 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI GEBELEIN, BRIAN · 2008 to 2023
$4.5MBinding of Epstein Barr Virus EBNA2 Unifies Multiple Sclerosis Genetic MechanismsR01NS099068 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan, Matthew Tyson Weirauch · 2017 to 2026
$4.2MRole of first neocortical RNA-Operon in specification of neocortical projection neuronsR01NS075367 · NINDS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI RASIN, MLADEN ROKO · 2011 to 2021
$3.4MRepairing maladaptive corticospinal tract developmentR01NS079569 · NINDS · CITY COLLEGE OF NEW YORK · PI MARTIN, JOHN H · 2013 to 2017
$1.7MEffect of disease-associated genetic variants on viral protein DNA bindingR21HG008186 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI WEIRAUCH, MATTHEW TYSON · 2015 to 2017
$464kMolecular Control of Corticospinal System Formation by Intermediate TargetsK99NS064303 · NINDS · YALE UNIVERSITY · PI RASIN, MLADEN ROKO · 2009 to 2009
$97kNEI NIH HHS P30 EY012196NHGRI NIH HHS R21 HG008186NIGMS NIH HHS R01 GM079428NIMH NIH HHS P50 MH106934NIMH NIH HHS U01 MH103339NINDS NIH HHS K99 NS064303NINDS NIH HHS R01 NS075367NINDS NIH HHS R01 NS079569NINDS NIH HHS R01 NS093002NINDS NIH HHS R01 NS099068
Abstract
Superior manual dexterity in higher primates emerged together with the appearance of cortico-motoneuronal (CM) connections during the evolution of the mammalian corticospinal (CS) system. Previously thought to be specific to higher primates, we identified transient CM connections in early postnatal mice, which are eventually eliminated by Sema6D-PlexA1 signaling.
Indexed as
Gene Expression RegulationAnimalsDNA-Binding ProteinsEmpty Spiracles Homeobox ProteinsEvolution, MolecularFunctional LateralityHomeodomain ProteinsMiceMice, Mutant StrainsMotor CortexMotor NeuronsNerve Tissue ProteinsPromoter Regions, GeneticPyramidal TractsReceptors, Cell SurfaceSemaphorinsDNA-Binding ProteinsEmpty Spiracles Homeobox ProteinsHomeodomain ProteinsNerve Tissue ProteinsPlxna1 protein, mouseReceptors, Cell SurfaceSema6d protein, mouseSemaphorinsTranscription FactorsZfp312 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.