ArticleArteriosclerosis, thrombosis, and vascular biology2017
Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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19citing papers in PubMed, 2 pooled it
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study.BMC medicine · 2023Pooled it
- Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Hyperadhesive von Willebrand Factor Contributes to Pathogenesis of Preeclampsia.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- New Frontiers in the Pathophysiology of Hypertensive Pregnancy Disorders: A Systematic Review of Molecular Insights into Preeclampsia.Current issues in molecular biology · 2026Review
- Article
- A Disintegrin and Metalloprotease with Thrombospondin Motif, Member 13, and Von Willebrand Factor in Relation to the Duality of Preeclampsia and HIV Infection.International journal of molecular sciences · 2025Review
- Thrombotic Microangiopathy in Pregnancy: Current Understanding and Management Strategies.Kidney international reports · 2024Review
- Increased Complement Activation and Decreased ADAMTS13 Activity Are Associated with Genetic Susceptibility in Patients with Preeclampsia/HELLP Syndrome Compared to Healthy Pregnancies: An Observational Case-Controlled Study.Journal of personalized medicine · 2024Article
- ADAMTS13 regulates angiogenic markers via Ephrin/Eph signaling in human mesenchymal stem cells under serum-deprivation stress.Scientific reports · 2024Article
- SARS CoV-2 infection as a risk factor of preeclampsia and pre-term birth. An interplay between viral infection, pregnancy-specific immune shift and endothelial dysfunction may lead to negative pregnancy outcomes.Annals of medicine · 2023Review
- Etiology and outcomes: Thrombotic microangiopathies in pregnancy.Research and practice in thrombosis and haemostasis · 2023Article
- Hypercoagulability and Inflammatory Markers in a Case of Congenital Thrombotic Thrombocytopenic Purpura Complicated by Fetal Demise.Journal of clinical medicine · 2022Article
- Maternal and fetal outcomes of pregnancy occurring after a diagnosis of immune-mediated thrombotic thrombocytopenic purpura.Annals of hematology · 2022Article
- [Relationship Between ABO Blood Group and Pregnancy Complications].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Molecular Advances in Preeclampsia and HELLP Syndrome.International journal of molecular sciences · 2022Review
- Biological potentials for a family of disintegrin and metalloproteinase (ADAMDEC)-1 in mouse normal pregnancy.The Journal of veterinary medical science · 2021Article
- The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Reporting Sex and Sex Differences in Preclinical Studies.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Non-O blood group and outcomes of in vitro fertilization.Journal of assisted reproduction and genetics · 2018Observational
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Authors and funding
12 authors at 2 institutions in 1 country.
Juan XiaoFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Yun FengFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Xueyin LiFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Wei LiFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Lei FanFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Jing LiuFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Xue ZengFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Kaiyue ChenFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Xi ChenFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
Xiaoshui ZhouFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.).
X Long ZhengFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.). tj_csh@163.com xzheng@uabmc.edu.
Suhua ChenFrom the Department of Obstetrics & Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.X., Y.F., W.L., L.F., J.L., X. Zeng, K.C., X.C., S.C.); Department of Urology, Zhengzhou First People's Hospital, Henan, China (X.L.); Department of Obstetrics & Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China (X. Zhou); and Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham (X.L.Z.). tj_csh@163.com xzheng@uabmc.edu.
Second Affiliated Hospital of Zhengzhou University · CNZhengzhou People's Hospital · CN
Funding
Pathogenesis of Thrombotic MicroangiopathyR01HL126724 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHENG, X. LONG · 2015 to 2018
$1.8MNovel Therapeutics for Acquired Thrombotic Thrombocytopenic PurpuraR01HL115187 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHENG, X. LONG · 2013 to 2016
$1.6MNHLBI NIH HHS R01 HL115187NHLBI NIH HHS R01 HL126724
Abstract
objectiveADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 repeats, member 13) is primarily synthesized in liver. The biosynthesis of ADAMTS13 and its physiological role in placenta are not known. APPROACH AND
resultsWe used real-time polymerase chain reaction, immunohistochemistry, and Western blotting analyses, as well as proteolytic cleavage of FRETS (fluorescent resonance energy transfers)-VWF73, to determine ADAMTS13 expression in placenta and trophoblasts obtained from individuals with normal pregnancy and patients with severe preeclampsia. We also determined the role of ADAMTS13 in extravillous trophoblasts using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, wound scratch assay, transwell migration assay, tube formation assay, and tissue outgrowth assays. We showed that full-length and proteolytically active ADAMTS13 was expressed in normal human placenta, primarily in the trophoblasts and villous core fetal vessel endothelium during pregnancy. Placental expression of
conclusionsOur results demonstrate for the first time the expression of
Indexed as
Neovascularization, PhysiologicPlacentationADAMTS13 ProteinAdultAnimalsCase-Control StudiesCell MovementCell ProliferationCHO CellsCricetulusEndothelial CellsFemaleGene Expression Regulation, DevelopmentalHumansPlacentaPre-EclampsiaADAMTS13 ProteinADAMTS13 protein, humanRNA, Messengervon Willebrand FactorADAMTS13placentapreeclampsiaprotein synthesistrophoblast
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