Evidence map›Paper›PMID 28751572›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study.

Wenyuan Li, Kirsten S Dorans, Elissa H Wilker, Mary B Rice, Petter L Ljungman, Joel D Schwartz, Brent A Coull, Petros Koutrakis, Diane R Gold, John F Keaney and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.

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  17. Long-term exposure to PMJournal of advanced research · 2024
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Wenyuan LiFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Kirsten S DoransFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Elissa H WilkerFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Mary B RiceFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Petter L LjungmanFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Joel D SchwartzFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Brent A CoullFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Petros KoutrakisFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Diane R GoldFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
John F KeaneyFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Ramachandran S VasanFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Emelia J BenjaminFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.).
Murray A MittlemanFrom the Departments of Epidemiology (W.L., K.S.D., E.H.W., J.D.S., M.A.M.), Environmental Health (J.D.S., P.K., D.R.G.), and Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Division of Cardiology (W.L., K.S.D., E.H.W., P.L.L., M.A.M.) and Division of Pulmonary, Critical Care and Sleep Medicine (M.B.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (P.L.L.); Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (D.R.G.); Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester (J.F.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (R.S.V., E.J.B.); Preventive Medicine and Cardiology Sections, Department of Medicine, Boston University School of Medicine, MA (R.S.V., E.J.B.); and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V., E.J.B.). mmittlem@hsph.harvard.edu.
Harvard University · USFramingham Heart Study · USKarolinska Institutet · SEBoston University · USNational Heart Lung and Blood Institute · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BUTLER, JAVED · 2013 to 2017
$20.1M
Effect of Ambient Particles on Acute Stroke OnsetP01ES009825 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GOLD, DIANE R · 1999 to 2009
$17.4M
Training Program in the Epidemiology of CVDT32HL007575 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BURING, JULIE E., RIDKER, PAUL M. · 1985 to 2019
$5.0M
Framingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9M
AFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1M
Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham StudyR01AG028321 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2006 to 2010
$1.8M
Air Pollution and the Lung in Health and COPD: Obstructive, Restrictive and Vascular PathwaysK23ES026204 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICE, MARY B · 2016 to 2020
$883k
Traffic pollution, brain structure and cognitive functionR00ES022243 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WILKER, ELISSA · 2016 to 2018
$747k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL128914NHLBI NIH HHS T32 HL007575NIA NIH HHS R01 AG028321NIEHS NIH HHS K23 ES026204NIEHS NIH HHS P01 ES009825NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R00 ES022243
6 · The paper itself

Abstract

objectiveThe objective of this study is to examine associations between short-term exposure to ambient air pollution and circulating biomarkers of systemic inflammation in participants from the Framingham Offspring and Third Generation cohorts in the greater Boston area. APPROACH AND

resultsWe included 3996 noncurrent smoking participants (mean age, 53.6 years; 54% women) who lived within 50 km from a central air pollution monitoring site in Boston, MA, and calculated the 1- to 7-day moving averages of fine particulate matter (diameter<2.5 µm), black carbon, sulfate, nitrogen oxides, and ozone before the examination visits. We used linear mixed effects models for C-reactive protein and tumor necrosis factor receptor 2, which were measured up to twice for each participant; we used linear regression models for interleukin-6, fibrinogen, and tumor necrosis factor α, which were measured once. We adjusted for demographics, socioeconomic position, lifestyle, time, and weather. The 3- to 7-day moving averages of fine particulate matter (diameter<2.5 µm) and sulfate were positively associated with C-reactive protein concentrations. A 5 µg/m

conclusionsHigher short-term exposure to relatively low levels of ambient air pollution was associated with higher levels of C-reactive protein, interleukin-6, and tumor necrosis factor receptor 2 but not fibrinogen or tumor necrosis factor α in individuals residing in the greater Boston area.

Indexed as

AdultAgedAir PollutantsBiomarkersBostonC-Reactive ProteinEnvironmental MonitoringFemaleHumansInflammationInflammation MediatorsInhalation ExposureInterleukin-6MaleMiddle AgedParticle SizeAir PollutantsBiomarkersC-Reactive ProteinIL6 protein, humanInflammation MediatorsInterleukin-6Particulate MatterReceptors, Tumor Necrosis Factor, Type IITNFRSF1B protein, humanair pollutionbiomarkersepidemiologyinflammationparticulate matter

Identifiers

PMID28751572
PMCPMC5570664
OpenAlexW2741800441

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