Evidence map›Paper›PMID 28751566›Full record

Trial reportHaematologica2017

Prolonged

Veerle Mondelaers, Stefan Suciu, Barbara De Moerloose, Alina Ferster, Françoise Mazingue, Geneviève Plat, Karima Yakouben, Anne Uyttebroeck, Patrick Lutz, Vitor Costa and 14 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03911128 recruitingnot on this mapstarted 2019, after this paper: background citation

A Treatment Study Protocol of the ALLTogether Consortium for Infants, Children and Young Adults (0-45 Years of Age) With Newly Diagnosed Acute Lymphoblastic Leukaemia (ALL): a Pilot Study

TypeobservationalSponsorMats HeymanRan2019 to 2033Enrolled500ConditionsLeukemia, Acute LymphoblasticArmsObservational
NCT04307576 phase3recruitingnot on this mapstarted 2020, after this paper: background citation

ALLTogether1 - A Treatment Study Protocol of the ALLTogether Consortium for Children and Young Adults (0-45 Years of Age) With Newly Diagnosed Acute Lymphoblastic Leukaemia (ALL)

TypeinterventionalSponsorMats HeymanRan2020 to 2033Enrolled6,430ConditionsLeukemia, Acute LymphoblasticArmsOmitted Doxorubicin, Omitted Vincristine+Dexamethasone pulses, Inotuzumab Ozogamicin+Standard Maintenance Therapy, Imatinib, 6-tioguanine+Standard Maintenance Therapy
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. The frequency ofFrontiers in oncology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Favorable Trisomies andJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Asparaginase: an old drug with new questions.Hematology, transfusion and cell therapy
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 20 institutions in 3 countries.

Veerle MondelaersDepartment of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent University, Belgium veerle.mondelaers@uzgent.be.
Stefan SuciuEORTC Headquarters, Brussels, Belgium.
Barbara De MoerlooseDepartment of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent University, Belgium.
Alina FersterDepartment of Pediatric Hematology-Oncology, Children's University Hospital Queen Fabiola, Université Libre de Bruxelles (ULB), Belgium.
Françoise MazingueDepartment of Pediatric Hematology-Oncology, CHRU, Lille, France.
Geneviève PlatDepartment of Pediatric Hematology-Oncology, CHU-Hopital Purpan, Toulouse, France.
Karima YakoubenDepartment of Pediatric Hematology, Robert Debré Hospital, AP-HP, Paris, France.
Anne UyttebroeckDepartment of Pediatric Hematology-Oncology, University Hospital Gasthuisberg, Leuven, Belgium.
Patrick LutzDepartment of Pediatric Hematology-Oncology, University Hospital Hautepierre, Strasbourg, France.
Vitor CostaDepartment of Pediatrics, Portuguese Oncology Institute, Porto, Portugal.
Nicolas SirventDepartment of Pediatric Hematology-Oncology, CHU, Montpellier, France.
Emmanuel PlouvierPediatric Hematology Unit, CHU Jean Minjoz Hospital, Besançon, France.
Martine MunzerDepartment of Pediatric Hematology-Oncology, American Memorial Hospital, Reims, France.
Maryline PoiréeDepartment of Pediatric Hematology-Oncology, CHU Lenval, Nice, France.
Odile MinckesDepartment of Pediatric Hematology-Oncology, CHU, Caen, France.
Frédéric MillotPediatric Oncology Unit, University Hospital, Poitiers, France.
Dominique PlantazDepartment of Pediatric Oncology, University Hospital, Grenoble, France.
Philip MaesDepartment of Pediatrics, University Hospital Antwerp, Belgium.
Claire HoyouxDepartment of Pediatrics, CHR de la Citadelle, Liège, Belgium.
Hélène CavéDepartment of Genetics, Assistance Publique des Hôpitaux de Paris (AP-HP), Robert Debré Hospital, Paris, France.
Pierre RohrlichDepartment of Pediatric Hematology-Oncology, CHU Lenval, Nice, France.
Yves BertrandInstitute of Pediatric Hematology and Oncology (IHOP), Hospices Civils de Lyon, and University Lyon 1, France.
Yves BenoitDepartment of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent University, Belgium.
Children–s Leukemia Group (CLG) of the European Organization for Research and Treatment of Cancer (EORTC)
Ghent University Hospital · BECentre Hospitalier Universitaire de Nice · FRAssistance Publique – Hôpitaux de Paris · FRCentre hospitalier régional de la Citadelle · BECentre Hospitalier Universitaire de Besançon · FRCentre Hospitalier Universitaire de Caen Normandie · FRCentre Hospitalier Universitaire de Lille · FRCentre Hospitalier Universitaire de Poitiers · FRCentre Hospitalier Universitaire de Reims · FRCentre Hospitalier Universitaire de Toulouse · FREuropean Organisation for Research and Treatment of Cancer · BEHôpital d'Hautepierre · FRInserm · FRInstituto Português de Oncologia Francisco Gentil · PTKU Leuven · BEUniversité Claude Bernard Lyon 1 · FRUniversité de Montpellier · FRUniversité Grenoble Alpes · FRUniversité Libre de Bruxelles · BEUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asparaginase is an essential component of combination chemotherapy for childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma. The value of asparaginase was further addressed in a group of non-very high-risk patients by comparing prolonged (long-asparaginase)

Indexed as

AdolescentAntineoplastic AgentsAsparaginaseChildChild, PreschoolConsolidation ChemotherapyEscherichia coli ProteinsFemaleHumansInduction ChemotherapyInfantLymphoma, Non-HodgkinMalePrecursor Cell Lymphoblastic Leukemia-LymphomaSurvival AnalysisTime FactorsAntineoplastic AgentsAsparaginaseEscherichia coli Proteins

Identifiers

PMID28751566
PMCPMC5622857
OpenAlexW2740228493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.