Trial reportAJNR. American journal of neuroradiology2017
Value of Thrombus CT Characteristics in Patients with Acute Ischemic Stroke.
Trial report in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Value of thrombus imaging in predicting the outcomes of patients with large-vessel occlusive strokes after endovascular therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- Trial
- Analysis of the baseline multiphase computed tomographic angiography findings to predict clinical outcomes in patients with middle cerebral artery M1 occlusion treated with mechanical thrombectomy.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- The role of computed tomography in thrombus characterization: Insights from a stroke cohort of known and unknown etiology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Correlation between imaging characteristics of deep venous thrombosis at computed tomography venography and acute pulmonary embolism.Quantitative imaging in medicine and surgery · 2025Article
- Subtype identification of clinical and thrombus imaging features in acute ischemic stroke: using clustering analysis and principal component analysis.Scientific reports · 2025Article
- Thrombus perviousness in acute ischemic stroke: a scoping review of methodology, predictive value, and future perspectives.Neuroradiology · 2025Article
- Association Between MR-Based Thrombus Imaging Characteristics and Endovascular Therapy Outcome in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2024Article
- Value of Automatically Derived Full Thrombus Characteristics: An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients.Journal of clinical medicine · 2024Article
- Utility of dual energy CT in differentiating clot in acute ischemic stroke.The neuroradiology journal · 2023Article
- Delayed neurological improvement after endovascular treatment for acute large vessel occlusion: data from ANGEL-ACT registry.Journal of thrombosis and thrombolysis · 2023Article
- Neuroimaging of Acute Ischemic Stroke: Multimodal Imaging Approach for Acute Endovascular Therapy.Journal of stroke · 2023Review
- Clot-based radiomics features predict first pass effect in acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Article
- Article
- Radiology-Pathology Correlations of Intracranial Clots: Current Theories, Clinical Applications, and Future Directions.AJNR. American journal of neuroradiology · 2021Review
- Usefulness of deep learning-assisted identification of hyperdense MCA sign in acute ischemic stroke: comparison with readers' performance.Japanese journal of radiology · 2020Article
- Article
- Peri-thrombus vascular hyperintensity sign: detection of intracranial thrombus location and length in acute ischemic stroke.Japanese journal of radiology · 2020Article
- Clot permeability and histopathology: is a clot's perviousness on CT imaging correlated with its histologic composition?Journal of neurointerventional surgery · 2020Article
- Thrombus perviousness is not associated with first-pass revascularization using stent retrievers.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2019Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThrombus CT characteristics might be useful for patient selection for intra-arterial treatment. Our objective was to study the association of thrombus CT characteristics with outcome and treatment effect in patients with acute ischemic stroke. MATERIALS AND
methodsWe included 199 patients for whom thin-section NCCT and CTA within 30 minutes from each other were available in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute ischemic stroke in the Netherlands (MR CLEAN) study. We assessed the following thrombus characteristics: location, distance from ICA terminus to thrombus, length, volume, absolute and relative density on NCCT, and perviousness. Associations of thrombus characteristics with outcome were estimated with univariable and multivariable ordinal logistic regression as an OR for a shift toward better outcome on the mRS. Interaction terms were used to investigate treatment-effect modification by thrombus characteristics.
resultsIn univariate analysis, only the distance from the ICA terminus to the thrombus, length of >8 mm, and perviousness were associated with functional outcome. Relative thrombus density on CTA was independently associated with functional outcome with an adjusted common OR of 1.21 per 10% (95% CI, 1.02-1.43;
conclusionsIn our study on patients with large-vessel occlusion of the anterior circulation, CT thrombus characteristics appear useful for predicting functional outcome. However, in our study cohort, the effect of intra-arterial treatment was independent of the thrombus CT characteristics. Therefore, no arguments were provided to select patients for intra-arterial treatment using thrombus CT characteristics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.