Evidence map›Paper›PMID 28751503›Full record

ArticleG3 (Bethesda, Md.)2017

Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria.

Hong Ming Huang, Denis C Bauer, Patrick M Lelliott, Matthew W A Dixon, Leann Tilley, Brendan J McMorran, Simon J Foote, Gaetan Burgio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022
    Review
  2. Article
  3. Host genetics in malaria: lessons from mouse studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hong Ming HuangDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia.ORCID 0000-0001-5698-8116
Denis C BauerCommonwealth Scientific and Industrial Research Organisation, Sydney 2113, Australia.ORCID 0000-0001-8033-9810
Patrick M LelliottImmunology Frontier Research Center Research Building, Osaka University, Suita, 565-0871, Japan.
Matthew W A DixonDepartment of Biochemistry and Molecular Biology, Bio21 Institute, Melbourne 3052, Australia.ORCID 0000-0001-9732-9686
Leann TilleyDepartment of Biochemistry and Molecular Biology, Bio21 Institute, Melbourne 3052, Australia.ORCID 0000-0001-9910-0199
Brendan J McMorranDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia.ORCID 0000-0003-1845-8872
Simon J FooteDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia.ORCID 0000-0002-9142-2107
Gaetan BurgioDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia Gaetan.burgio@anu.edu.au.ORCID 0000-0002-7434-926X
Australian National University · AUCommonwealth Scientific and Industrial Research Organisation · AUOsaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allelic heterogeneity is a common phenomenon where a gene exhibits a different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it allowed us to explore and understand the intricate host-parasite interactions during malaria infections. In this study, we described a gene encoding erythrocytic ankyrin-1 (

Indexed as

AllelesGenetic HeterogeneityGenetic Predisposition to DiseaseAnimalsAnkyrinsDisease Models, AnimalDisease ResistanceErythrocytesFemaleHost-Parasite InteractionsMalariaMaleMiceMutationOsmotic FragilityPhenotypeAnkyrinsallelic heterogeneityankyrin-1erythrocyte cytoskeletonmalaria

Identifiers

PMID28751503
PMCPMC5592938
OpenAlexW2950095960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.