ArticleThe European respiratory journal2017
Evaluating 17 years of latent tuberculosis infection screening in north-west England: a retrospective cohort study of reactivation.
Article in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review of latent tuberculosis infection research to inform programmatic management in Ireland.Irish journal of medical science · 2022Pooled it
- Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings.Nature medicine · 2020Pooled it
- Effectiveness of interventions for reducing TB incidence in countries with low TB incidence: a systematic review of reviews.European respiratory review : an official journal of the European Respiratory Society · 2019Pooled it
- Latent tuberculosis infection screening in patients with inflammatory bowel disease: a nationwide retrospective cohort study in South Korea comparing IGRA alone versus a combination of TST and IGRA.Intestinal research · 2025Article
- The impact of latent tuberculosis screening programmes for migrant populations in high income, low burden countries.PloS one · 2025Article
- Tuberculosis screening in the European migrant population: a scoping review of current practices.Breathe (Sheffield, England) · 2024Article
- Anti-tuberculosis treatment strategies and drug development: challenges and priorities.Nature reviews. Microbiology · 2022Review
- Diagnosis of tuberculosis in dialysis and kidney transplant patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2022Article
- Article
- Effectiveness of nationwide programmatic testing and treatment for latent tuberculosis infection in migrants in England: a retrospective, population-based cohort study.The Lancet. Public health · 2022Article
- Targeting screening and treatment for latent tuberculosis infection towards asylum seekers from high-incidence countries - a model-based cost-effectiveness analysis.BMC public health · 2021Article
- Validation of Differentially Expressed Immune Biomarkers in Latent and Active Tuberculosis by Real-Time PCR.Frontiers in immunology · 2020Article
- One Step toward a Low Tuberculosis-Burden Country: Screening for Tuberculosis Infection among the Immigrants and Refugees.Tuberculosis and respiratory diseases · 2020Article
- Screening and treatment for tuberculosis in a cohort of unaccompanied minor refugees in Berlin, Germany.PloS one · 2019Article
- Towards TB Elimination in Aotearoa/New Zealand: Key Informant Insights on the Determinants of TB among African Migrants.Tropical medicine and infectious disease · 2018Article
- Tuberculosis control in the Republic of Korea.Epidemiology and health · 2018Article
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5 authors.
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Abstract
Approximately 72% of tuberculosis (TB) cases in England occur among non-UK born individuals, mostly as a result of reactivation of latent TB infection (LTBI). Programmatic LTBI screening is a key intervention of the TB strategy for England. This article reviews the results of a long-standing LTBI screening initiative in England.A retrospective cohort was created through probabilistic linkage between LTBI screening data and national TB case notifications. Screened persons were followed until they died, became a case, emigrated or until cohort-end. TB incidence rates and rate ratios (IRR) were calculated.97 out of 1820 individuals screened for LTBI were reported to have active TB. Crude incidence rates among LTBI-positive, treatment-naïve individuals were 4.1 and 2.3 per 100 person-years in the QuantiFERON and tuberculin skin test cohorts, respectively. Among the QuantiFERON cohort, Poisson regression showed that LTBI positivity (IRR 22.6, 95% CI 6.8-74.6) and no chemoprophylaxis increased the probability of becoming a TB case (IRR 0.17, 95% CI 0.05-0.6).We found high TB rates in LTBI-positive, treatment-naïve individuals and a strong association between no treatment and becoming a TB case, demonstrating feasibility and effectiveness of LTBI screening and providing important policy lessons for LTBI screening in England and beyond.
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