Evidence map›Paper›PMID 28751378›Full record

ArticleThe Journal of biological chemistry2017

Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins.

Wojtek Steffen, Fu Chong Ko, Jigar Patel, Victor Lyamichev, Thomas J Albert, Jörg Benz, Markus G Rudolph, Frank Bergmann, Thomas Streidl, Peter Kratzsch and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
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  12. Article
  13. Transglutaminase in Foods and Biotechnology.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. Molecular dynamics analysis of the structural properties of the transglutaminases ofComputational and structural biotechnology journal · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Wojtek SteffenFrom Roche Diagnostics GmbH, CPS, Nonnenwald 2, 82377 Penzberg, Germany, wojtek.steffen@roche.com.
Fu Chong KoFrom Roche Diagnostics GmbH, CPS, Nonnenwald 2, 82377 Penzberg, Germany.
Jigar PatelRoche Sequencing, NimbleGen, Madison, Wisconsin 53719, and.
Victor LyamichevRoche Sequencing, NimbleGen, Madison, Wisconsin 53719, and.
Thomas J AlbertRoche Sequencing, NimbleGen, Madison, Wisconsin 53719, and.
Jörg BenzF. Hoffmann-La Roche Ltd., pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Markus G RudolphF. Hoffmann-La Roche Ltd., pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Frank BergmannFrom Roche Diagnostics GmbH, CPS, Nonnenwald 2, 82377 Penzberg, Germany.
Thomas StreidlFrom Roche Diagnostics GmbH, CPS, Nonnenwald 2, 82377 Penzberg, Germany.
Peter KratzschFrom Roche Diagnostics GmbH, CPS, Nonnenwald 2, 82377 Penzberg, Germany.
Mara Boenitz-DulatFrom Roche Diagnostics GmbH, CPS, Nonnenwald 2, 82377 Penzberg, Germany.
Tobias OelschlaegelFrom Roche Diagnostics GmbH, CPS, Nonnenwald 2, 82377 Penzberg, Germany.
Michael SchraemlFrom Roche Diagnostics GmbH, CPS, Nonnenwald 2, 82377 Penzberg, Germany.
Roche Pharma AG (Germany) · DERoche (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial transglutaminases (MTGs) catalyze the formation of Gln-Lys isopeptide bonds and are widely used for the cross-linking of proteins and peptides in food and biotechnological applications (

Indexed as

ActinomycetalesBinding SitesModels, MolecularPeptidesProtein ConformationProteinsStaining and LabelingSubstrate SpecificityTransglutaminasesPeptidesProteinsTransglutaminasesantibody-drug conjugatesantibody engineeringbio-orthogonalbiotechnologyenzyme structurehigh-throughput screening (HTS)Kutzneria albidapeptide arraysite-specific conjugationtransglutaminase

Identifiers

PMID28751378
PMCPMC5612097
OpenAlexW2740349387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.