ArticleArchives of physical medicine and rehabilitation2018
Modification of Spastic Stretch Reflexes at the Elbow by Flexion Synergy Expression in Individuals With Chronic Hemiparetic Stroke.
Article in Archives of physical medicine and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Myoelectric Computer Interface Training for Reducing Co-Activation and Enhancing Arm Movement in Chronic Stroke Survivors: A Randomized Trial.Neurorehabilitation and neural repair · 2019Trial
- Review
- Quantitative assessment of dynamic movement reveals deficits due to hemiparetic stroke.Journal of neuroengineering and rehabilitation · 2025Article
- Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.Medical hypotheses · 2025Article
- How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?Medical hypotheses · 2024Article
- Perturbation-induced electromyographic activity is predictive of flexion synergy expression and a sensitive measure of post-stroke motor impairment.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- The benefit of knowledge: postural response modulation by foreknowledge of equilibrium perturbation in an upper limb task.European journal of applied physiology · 2024Article
- Implications of Hemispheric Shift of Sensory Feedback during Post-stroke Motor Control on Personalized Stroke Rehabilitation.Converging clinical and engineering research on neurorehabilitation V : proceedings of the 6th International Conference on Neurorehabilitation (ICNR 2024), November 5-8, 2024, La Granja, Spain. Volume 2 · 2024Article
- Peripheral nerve blocks of wrist and finger flexors can increase hand opening in chronic hemiparetic stroke.Frontiers in neurology · 2024Article
- A Method for Quantification of Stretch Reflex Excitability During Ballistic Reaching.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Cortical Reorganization of Early Somatosensory Processing in Hemiparetic Stroke.Journal of clinical medicine · 2022Article
- Development of a single device to quantify motor impairments of the elbow: proof of concept.Journal of neuroengineering and rehabilitation · 2022Article
- Impact of Voluntary Muscle Activation on Stretch Reflex Excitability in Individuals With Hemiparetic Stroke.Frontiers in neurology · 2022Article
- Passive Properties of the Wrist and Fingers Following Chronic Hemiparetic Stroke: Interlimb Comparisons in Persons With and Without a Clinical Treatment History That Includes Botulinum Neurotoxin.Frontiers in neurology · 2021Article
- Temporal Dynamics of Corticomuscular Coherence Reflects Alteration of the Central Mechanisms of Neural Motor Control in Post-Stroke Patients.Frontiers in human neuroscience · 2021Article
- Assessing the Usage of Indirect Motor Pathways Following a Hemiparetic Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
- Assessing Neural Connectivity and Associated Time Delays of Muscle Responses to Continuous Position Perturbations.Annals of biomedical engineering · 2021Article
- Quantifying Altered Neural Connectivity of the Stretch Reflex in Chronic Hemiparetic Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- Virtual reality-based balance training system augmented with operant conditioning paradigm.Biomedical engineering online · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo systematically characterize the effect of flexion synergy expression on the manifestation of elbow flexor stretch reflexes poststroke, and to relate these findings to elbow flexor stretch reflexes in individuals without neurologic injury.
designControlled cohort study.
settingAcademic medical center.
participantsParticipants (N=20) included individuals with chronic hemiparetic stroke (n=10) and a convenience sample of individuals without neurologic or musculoskeletal injury (n=10).
interventionsParticipants with stroke were interfaced with a robotic device that precisely manipulated flexion synergy expression (by regulating shoulder abduction loading) while delivering controlled elbow extension perturbations over a wide range of velocities. This device was also used to elicit elbow flexor stretch reflexes during volitional elbow flexor activation, both in the cohort of individuals with stroke and in a control cohort. In both cases, the amplitude of volitional elbow flexor preactivation was matched to that generated involuntarily during flexion synergy expression.
main outcome measuresThe amplitude of short- and long-latency stretch reflexes in the biceps brachii, assessed by electromyography, and expressed as a function of background muscle activation and stretch velocity.
resultsIncreased shoulder abduction loading potentiated elbow flexor stretch reflexes via flexion synergy expression in the paretic arm. Compared with stretch reflexes in individuals without neurologic injury, paretic reflexes were larger at rest but were approximately equal to control muscles at matched levels of preactivation.
conclusionsBecause flexion synergy expression modifies stretch reflexes in involved muscles, interventions that reduce flexion synergy expression may confer the added benefit of reducing spasticity during functional use of the arm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.