Trial reportThe Journal of pediatrics2017
Caregiver-Reported Quality of Life in Youth with Down Syndrome.
Trial report in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01821300 (Cardiometabolic Risk and Obesity in Adolescents With Down Syndrome), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiometabolic Risk and Obesity in Adolescents With Down Syndrome
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- The combination of atomoxetine and oxybutynin for the treatment of obstructive sleep apnea in children with Down syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- Mediating Effects of Parental Family Adaptation on the Quality of Life of Children With Down Syndrome: A Study of Father-Mother Dyads.Journal of advanced nursing · 2026Article
- Caregiver Interviews Regarding Health in Down Syndrome.American journal of medical genetics. Part A · 2026Observational
- Between care and collapse: the hidden health and emotional struggles of Saudi mothers of children with Down syndrome.Frontiers in psychology · 2026Article
- Article
- The impact of Down syndrome on patients' caregivers: a survey of an Italian paediatric cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Caregivers of children with Down Syndrome adapt their child's diet and experience barriers and impacts on quality of life.International journal of pediatric otorhinolaryngology · 2025Observational
- Quality of Life for Patients with Down Syndrome and Their Caregivers: A Cross-Sectional Study from a Parental Perspective in Saudi Arabia.Healthcare (Basel, Switzerland) · 2025Article
- Instruments for the assessment of quality of life in children and adolescents with Down syndrome: a scoping review.BMC pediatrics · 2024Article
- Disorders of Gut-Brain Interaction in a National Cohort of Children With Down Syndrome.Journal of neurogastroenterology and motility · 2023Article
- Health-related quality of life and family functioning of primary caregivers of children with down syndrome.Frontiers in psychiatry · 2023Article
- Differential expression of cystathionine beta synthase in adolescents with Down syndrome: impact on adiposity.Journal of diabetes and metabolic disorders · 2022Article
- The quality of life of parents of children with down syndrome in a tertiary care hospital: A qualitative research study at Saudi Arabia.Annals of medicine and surgery (2012) · 2022Article
- New Challenges with Treatment Advances in Newborn Infants with Genetic Disorders and Severe Congenital Malformations.Children (Basel, Switzerland) · 2022Review
- Parental perspectives on the quality of life of children with Down syndrome.Frontiers in psychiatry · 2022Article
- Assessing Health-Related Quality of Life, Morbidity, and Survival Status for Individuals With Down Syndrome in Pakistan (DS-Pak): Protocol for a Web-Based Collaborative Registry.JMIR research protocols · 2021Article
- Family Variables and Quality of Life in Children with Down Syndrome: A Scoping Review.International journal of environmental research and public health · 2021Article
- Coping strategies adopted by Iranian families of children with Down syndrome: A qualitative study.Medicine · 2020Article
- Quality of life and comprehensive health supervision for children with Down syndrome in Thailand.Journal of community genetics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo describe caregiver-reported quality of life (QOL) in youth with Down syndrome (DS) and to examine the role of obesity on QOL. STUDY
designCaregivers of youth with and without DS aged 10 through 20 years completed questionnaires examining QOL (Pediatric Quality of Life Questionnaire) and weight-related QOL (Impact of Weight on Quality of Life - Kids). Age- and sex-specific z scores were generated for body mass index. Obesity was defined as a body mass index ≥95th percentile for age and sex.
resultsCaregiver-reported Total QOL, Physical Health, and Psychosocial Health summary scores were all lower in the DS group compared with the non-DS controls (P < .001). Social and School Functioning were also lower (P < .001), but Emotional Functioning did not differ between DS and non-DS groups (P = .31). Physical Functioning (P = .003) and Total scores (P = .03) differed between youth without DS with and without obesity, but no differences were reported between youth with DS with and without obesity. On the Impact of Weight on Quality of Life - Kids, caregivers of youth with DS reported greater Body Esteem (P = .020) and Social Life scores (P = .03) than caregivers of non-DS youth. Caregivers of youth with obesity, regardless of DS status, reported significantly lower weight-specific QOL scores than caregivers of youth without obesity.
conclusionCaregivers reported lower QOL in youth with DS compared with youth without DS with the exception of emotional functioning. Obesity influences most domains of weight-related QOL in youth with and without DS; therefore, providers should address weight concerns in youth with obesity even in the presence of DS. CLINICAL
trial registrationNCT01821300.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.