ArticleMedical engineering & physics2017
A coupled mitral valve-left ventricle model with fluid-structure interaction.
Article in Medical engineering & physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
- Postoperative transient left ventricular outflow tract obstruction after mitral valve surgery: A systematic review of anatomical and hemodynamic factors.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Patient-Specific Analysis of Ventricular Vortex Formation and Flow Energetics in Rheumatic and Calcific Mitral Stenosis.Annals of biomedical engineering · 2026Article
- A numerical framework for preprocedural prosthetic valve positioning and hemodynamic evaluation.Biomechanics and modeling in mechanobiology · 2025Article
- Three-dimensional fluid-structure interaction modelling of the venous valve using immersed boundary/finite element method.Computers in biology and medicine · 2025Article
- Right Ventricle Function: The Role of the Forgotten Chamber in Mitral Valve Surgery.Current cardiology reports · 2025Review
- Simulated Effects of Acute Left Ventricular Myocardial Infarction on Mitral Regurgitation in an Ovine Model.Journal of biomechanical engineering · 2024Article
- Preclinical Models of Cardiac Disease: A Comprehensive Overview for Clinical Scientists.Cardiovascular engineering and technology · 2024Review
- A simulation-based phantom model for generating synthetic mitral valve image data-application to MRI acquisition planning.International journal of computer assisted radiology and surgery · 2024Article
- An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse.Cardiovascular engineering and technology · 2023Article
- On the Lagrangian-Eulerian Coupling in the Immersed Finite Element/Difference Method.Journal of computational physics · 2022Article
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- CT-Based Analysis of Left Ventricular Hemodynamics Using Statistical Shape Modeling and Computational Fluid Dynamics.Frontiers in cardiovascular medicine · 2022Article
- A CFD study on the interplay of torsion and vortex guidance by the mitral valve on the left ventricular wash-out making use of overset meshes (Chimera technique).Frontiers in medical technology · 2022Article
- Fluid-structure interaction in a fully coupled three-dimensional mitral-atrium-pulmonary model.Biomechanics and modeling in mechanobiology · 2021Article
- Personalized intervention cardiology with transcatheter aortic valve replacement made possible with a non-invasive monitoring and diagnostic framework.Scientific reports · 2021Article
- A poroelastic immersed finite element framework for modelling cardiac perfusion and fluid-structure interaction.International journal for numerical methods in biomedical engineering · 2021Article
- The Comparison of Different Constitutive Laws and Fiber Architectures for the Aortic Valve on Fluid-Structure Interaction Simulation.Frontiers in physiology · 2021Article
- Computational fluid dynamics of the right atrium: Assessment of modelling criteria for the evaluation of dialysis catheters.PloS one · 2021Article
- Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy.Frontiers in physiology · 2021Article
- Functional Grading of a Transversely Isotropic Hyperelastic Model with Applications in Modeling Tricuspid and Mitral Valve Transition Regions.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Understanding the interaction between the valves and walls of the heart is important in assessing and subsequently treating heart dysfunction. This study presents an integrated model of the mitral valve (MV) coupled to the left ventricle (LV), with the geometry derived from in vivo clinical magnetic resonance images. Numerical simulations using this coupled MV-LV model are developed using an immersed boundary/finite element method. The model incorporates detailed valvular features, left ventricular contraction, nonlinear soft tissue mechanics, and fluid-mediated interactions between the MV and LV wall. We use the model to simulate cardiac function from diastole to systole. Numerically predicted LV pump function agrees well with in vivo data of the imaged healthy volunteer, including the peak aortic flow rate, the systolic ejection duration, and the LV ejection fraction. In vivo MV dynamics are qualitatively captured. We further demonstrate that the diastolic filling pressure increases significantly with impaired myocardial active relaxation to maintain a normal cardiac output. This is consistent with clinical observations. The coupled model has the potential to advance our fundamental knowledge of mechanisms underlying MV-LV interaction, and help in risk stratification and optimisation of therapies for heart diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.