Evidence map›Paper›PMID 28750682›Full record

ArticleAlzheimer's research & therapy2017

Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias.

Chris J D Hardy, Jennifer L Agustus, Charles R Marshall, Camilla N Clark, Lucy L Russell, Rebecca L Bond, Emilie V Brotherhood, David L Thomas, Sebastian J Crutch, Jonathan D Rohrer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Non-verbal dichotic listening: A new cognitive hearing test for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Speech perception and language comprehension in primary progressive aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Symptom-led staging for primary progressive aphasia.medRxiv : the preprint server for health sciences · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Laughter as a paradigm of socio-emotional signal processing in dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021
    Article
  12. Review
  13. Hearing and dementia: from ears to brain.Brain : a journal of neurology · 2021
    Review
  14. Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chris J D HardyDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Jennifer L AgustusDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Charles R MarshallDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Camilla N ClarkDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Lucy L RussellDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Rebecca L BondDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Emilie V BrotherhoodDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
David L ThomasDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Sebastian J CrutchDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
Jason D WarrenDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK. jason.warren@ucl.ac.uk.

Funding

Medical Research Council MR/J009482/1Medical Research Council MR/M008525/1Medical Research Council MR/M009106/1Medical Research Council MR/M023664/1Wellcome Trust
6 · The paper itself

Abstract

backgroundNon-verbal auditory impairment is increasingly recognised in the primary progressive aphasias (PPAs) but its relationship to speech processing and brain substrates has not been defined. Here we addressed these issues in patients representing the non-fluent variant (nfvPPA) and semantic variant (svPPA) syndromes of PPA.

methodsWe studied 19 patients with PPA in relation to 19 healthy older individuals. We manipulated three key auditory parameters-temporal regularity, phonemic spectral structure and prosodic predictability (an index of fundamental information content, or entropy)-in sequences of spoken syllables. The ability of participants to process these parameters was assessed using two-alternative, forced-choice tasks and neuroanatomical associations of task performance were assessed using voxel-based morphometry of patients' brain magnetic resonance images.

resultsRelative to healthy controls, both the nfvPPA and svPPA groups had impaired processing of phonemic spectral structure and signal predictability while the nfvPPA group additionally had impaired processing of temporal regularity in speech signals. Task performance correlated with standard disease severity and neurolinguistic measures. Across the patient cohort, performance on the temporal regularity task was associated with grey matter in the left supplementary motor area and right caudate, performance on the phoneme processing task was associated with grey matter in the left supramarginal gyrus, and performance on the prosodic predictability task was associated with grey matter in the right putamen.

conclusionsOur findings suggest that PPA syndromes may be underpinned by more generic deficits of auditory signal analysis, with a distributed cortico-subcortical neuraoanatomical substrate extending beyond the canonical language network. This has implications for syndrome classification and biomarker development.

Indexed as

Aphasia, Primary ProgressiveSpeechAcoustic StimulationAgedAged, 80 and overBrainCognition DisordersCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleMental Status ScheduleMiddle AgedPsychoacousticsAuditoryPrimary progressive aphasiaProgressive non-fluent aphasiaSemantic dementiaSpeechVoxel-based morphometry

Identifiers

PMID28750682
PMCPMC5531024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.