Evidence map›Paper›PMID 28750629›Full record

ReviewJournal of biomedical science2017

Role of free fatty acids in endothelial dysfunction.

Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M Siu, Christopher W K Lai

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of biomedical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
232citing papers in PubMed, 4 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

232 citing papers in PubMed, 4 syntheses or guidelines pooled it, 409 citations in OpenAlex.

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172 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Arijit GhoshDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, HKSAR, China.
Lei GaoDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, HKSAR, China.
Abhimanyu ThakurDepartment of Biomedical Sciences, City University of Hong Kong, HKSAR, China.
Parco M SiuDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, HKSAR, China.
Christopher W K LaiDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, HKSAR, China. chris.lai@polyu.edu.hk.
Hong Kong Polytechnic University · HKCity University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence showing that dysfunction of the vascular endothelium, the inner lining of the blood vessels, is the key player in the pathogenesis of atherosclerosis. In this review, we aimed to summarize the roles and the underlying mechanisms using the evidence collected from clinical and experimental studies about free fatty acid-mediated endothelial dysfunction. Because of the multifaceted roles of plasma free fatty acids in mediating endothelial dysfunction, elevated free fatty acid level is now considered as an important link in the onset of endothelial dysfunction due to metabolic syndromes such as diabetes and obesity. Free fatty acid-mediated endothelial dysfunction involves several mechanisms including impaired insulin signaling and nitric oxide production, oxidative stress, inflammation and the activation of the renin-angiotensin system and apoptosis in the endothelial cells. Therefore, targeting the signaling pathways involved in free fatty acid-induced endothelial dysfunction could serve as a preventive approach to protect against the occurrence of endothelial dysfunction and the subsequent complications such as atherosclerosis.

Indexed as

Signal TransductionAnimalsEndothelium, VascularFatty Acids, NonesterifiedHumansFatty Acids, NonesterifiedEndothelial dysfunctionFree fatty acidsInflammationInsulin resistanceNitric oxideOxidative stress

Identifiers

PMID28750629
PMCPMC5530532
OpenAlexW2740251705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.