Evidence map›Paper›PMID 28750577›Full record

ArticleInternational journal of STD & AIDS2018

Assessing Option B+ retention and infant follow-up in Lilongwe, Malawi.

Blake M Hauser, William C Miller, Hannock Tweya, Colin Speight, Tiwonge Mtande, Sam Phiri, L M Ball, Mina C Hosseinipour, Irving F Hoffman, Nora E Rosenberg

Abstract read
In one paragraph

Article in International journal of STD & AIDS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Blake M Hauser1 Department of Environmental Sciences and Engineering, 2331 University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
William C Miller2 Department of Medicine, 2331 University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
Hannock Tweya4 Lighthouse Trust, Lilongwe, Malawi.
Colin Speight4 Lighthouse Trust, Lilongwe, Malawi.
Tiwonge Mtande6 156288 University of North Carolina Project , Lilongwe, Malawi.
Sam Phiri2 Department of Medicine, 2331 University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
L M Ball1 Department of Environmental Sciences and Engineering, 2331 University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
Mina C Hosseinipour2 Department of Medicine, 2331 University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
Irving F Hoffman2 Department of Medicine, 2331 University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.
Nora E Rosenberg2 Department of Medicine, 2331 University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Option B+: ART Safety and Durability during First and Subsequent PregnanciesR01HD080485 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HOSSEINIPOUR, MINA CHRISTINE · 2014 to 2019
$3.9M
Developing and Assessing a Male Engagement Intervention for Option B+ in MalawiR00MH104154 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROSENBERG, NORA · 2017 to 2019
$746k
Developing and Assessing a Male Engagement Intervention for Option B+ in MalawiK99MH104154 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROSENBERG, NORA · 2015 to 2016
$168k
NIAID NIH HHS P30 AI050410NICHD NIH HHS R01 HD080485NIMH NIH HHS K99 MH104154NIMH NIH HHS R00 MH104154
6 · The paper itself

Abstract

Malawi launched Option B+, a program for all pregnant or breastfeeding HIV-positive women to begin lifelong combination antiretroviral therapy (cART), in July 2011. This study characterises a portion of the continuum of care within an antenatal setting in Lilongwe. Women testing HIV-positive and having a cART initiation record at Bwaila Antenatal Clinic from July 2013 to January 2014 were included. Using logistic regression models, we analysed relationships between maternal characteristics and return for infant testing. Among 490 HIV-positive women with a cART initiation record, 360 (73%) were retained at three months. Of these, 203 (56%) were adherent. Records of infant testing were located for 204 women (42%). Women who were not retained were less likely to have an early infant diagnosis record (aOR = 0.20; 95% CI: 0.10, 0.41). Among the women retained, there was a non-significant association between maternal adherence and infant testing (OR = 1.35; 95% CI: 0.89, 2.06). Women lost at earlier continuum stages, who are at higher risk for mother-to-child-transmission, were less likely to bring infants for testing. Even with a test-and-treat program, many women did not remain in care or bring their infant for testing. Facilitating strategies to improve these measures remains an important unmet need.

Indexed as

Continuity of Patient CareAdultAnti-HIV AgentsBreast FeedingFemaleFollow-Up StudiesHIV InfectionsHIV SeropositivityHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalLost to Follow-UpMalawiOutcome and Process Assessment, Health CarePatient ComplianceAnti-HIV AgentsAfricahighly active antiretroviral therapyHuman immunodeficiency viruspreventionwomen

Identifiers

PMID28750577
PMCPMC5920769

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.