ArticleJournal of evidence-based complementary & alternative medicine2017
The Analgesic and Anti-Inflammatory Activity of Linum usitatissimum in Balb/c Mice.
Article in Journal of evidence-based complementary & alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Topical analgesics for neuropathic pain: an evidence-informed guide for the practicing clinician.Pain medicine (Malden, Mass.) · 2026Review
- Utilizing the healing power of flaxseed: a narrative review of its therapeutic applications.Journal of diabetes and metabolic disorders · 2025Review
- Medicinal Plants for the Treatment of Neuropathic Pain: A Review of Randomized Controlled Trials.Current pharmaceutical biotechnology · 2024Review
- Evaluation of Biomedical Applications for Linseed Extract: Antimicrobial, Antioxidant, Anti-Diabetic, and Anti-Inflammatory Activities In Vitro.Journal of functional biomaterials · 2023Article
- Therapeutic Efficacy of a Formulation Prepared withPharmaceutics · 2023Article
- Ca' Granda,Molecules (Basel, Switzerland) · 2021Article
- Ethnopharmacological Knowledge for Management of Oral Mucositis in Zahedan, Southeast IranTurkish journal of pharmaceutical sciences · 2021Article
- Indian Medicinal Plants and Formulations and Their Potential Against COVID-19-Preclinical and Clinical Research.Frontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linum usitatissimum L is traditionally used for relief of pain and inflammation. In this study, the analgesic and anti-inflammatory effects of this plant were evaluated. Xylene test was used for anti-inflammatory evaluation in which 48 mice were randomly designated into 6 groups of 8 each including: control, dexamethasone as positive control (15 mg/kg), and experimental groups (42, 85, 170, and 340 mg/kg, respectively). For analgesic evaluation, 192 mice were randomly designated into 4 sets of 6 groups of 8 mice, including control, morphine as positive control, morphine plus naloxone, experimental groups (200 and 500 mg/kg extract), and extract along with naloxone group, which received 500 mg/kg. The analgesic activities were evaluated at 5, 15, 30, and 60 minutes, respectively, in each set. Both doses showed analgesic activity, the 200 mg/kg possessed higher effects ( P < .05). Naloxone reduced a section of its effect ( P < .001). The 170 mg/kg dose of the extract showed anti-inflammatory activity ( P < .05). The extract had phenolic, flavonoid, and flavonol compounds with antioxidant activity. Linum usitatissimum L dose dependently had analgesic activity partially like morphine and might be used as analgesic and anti-inflammatory agent.
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Registered trials
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