Evidence map›Paper›PMID 28750469›Full record

ArticleAmerican journal of perinatology2018

Maternal Gut Microbiome Biodiversity in Pregnancy.

Marcela C Smid, Nitasha M Ricks, Alexis Panzer, Amber N Mccoy, M Andrea Azcarate-Peril, Temitope O Keku, Kim A Boggess

Abstract read
In one paragraph

Article in American journal of perinatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. [Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
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  19. Review
  20. Host-gut microbiota interactions during pregnancy.Evolution, medicine, and public health · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marcela C SmidDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
Nitasha M RicksDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
Alexis PanzerSchool of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Amber N MccoyCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina.
M Andrea Azcarate-PerilCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina.
Kim A BoggessDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
NIDDK NIH HHS P30 DK034987NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

objectiveTo measure maternal gut microbiome biodiversity in pregnancy. MATERIALS AND

methodsIn phase 1, maternal fecal samples were collected by rectal swab in 20 healthy pregnant women (14-28 weeks gestation) to measure bacterial abundance. In phase 2, fecal samples were collected from 31 women at enrollment (<20 weeks gestation, baseline) and at 36 to 39 weeks of gestation (follow-up). We assessed cluster analysis to assess bacterial community profiles at the phylum level longitudinally through pregnancy. DNA was extracted from swabs, followed by PCR of the bacterial 16s rRNA gene and multiplex high-throughput sequencing (Ion Torrent).

resultsIn phase 1, 16 of 20 samples yielded usable data. White women (

conclusionMaternal microbiome biodiversity changes as pregnancy progresses and correlates with GWG.

Indexed as

BiodiversityGastrointestinal MicrobiomeGestational Weight GainBacteroidetesCluster AnalysisCross-Sectional StudiesFecesFemaleGastrointestinal TractGestational AgeHigh-Throughput Nucleotide SequencingHumansLongitudinal StudiesObesityPregnancyRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID28750469
PMCPMC6102712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.